Introduction：Basic information about CAS 10176-66-6|Nevadensin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Nevadensin |
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| CAS Number | 10176-66-6 | Molecular Weight | 344.31500 |
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| Density | 1.387g/cm3 | Boiling Point | 615ºC at 760 mmHg |
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| Molecular Formula | C18H16O7 | Melting Point | 199-200℃ (chloroform methanol ) |
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| MSDS | / | Flash Point | 227ºC |
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Names
| Name | nevadensin |
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| Synonym | More Synonyms |
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Nevadensin BiologicalActivity
| Description | Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1 (hCE1) with an IC50 of 2.64 μM. Nevadensin has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive[1][2]. |
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| Related Catalog | Research Areas >>InfectionResearch Areas >>Inflammation/ImmunologyResearch Areas >>Metabolic DiseaseSignaling Pathways >>Anti-infection >>Bacterial |
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| Target | IC50: 2.64 μM (hCE1), 132.8 μM (hCE2)[1] |
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Chemical & Physical Properties
| Density | 1.387g/cm3 |
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| Boiling Point | 615ºC at 760 mmHg |
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| Melting Point | 199-200℃ (chloroform methanol ) |
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| Molecular Formula | C18H16O7 |
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| Molecular Weight | 344.31500 |
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| Flash Point | 227ºC |
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| Exact Mass | 344.09000 |
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| PSA | 98.36000 |
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| LogP | 2.89700 |
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| Vapour Pressure | 1.02E-15mmHg at 25°C |
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| Index of Refraction | 1.627 |
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| InChIKey | KRFBMPVGAYGGJE-UHFFFAOYSA-N |
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| SMILES | COc1ccc(-c2cc(=O)c3c(O)c(OC)c(O)c(OC)c3o2)cc1 |
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2914509090 |
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Customs
| HS Code | 2914509090 |
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| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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Synonyms
| 5,7-dihydroxy-4',6,8-trimethoxyflavone |
| 5,7-Dihydroxy-6,8-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one |
| 5,7-Hexamethylene-2-thiaazulene-6-one |
| 5,7-hexamethylene-6H-cyclohepta[c]thiophen-6-one |
| 5,12-Methano-6H-cyclododeca[c]thiophen-14-one,6,7,8,9,10,11-hexahydro |
| 5,7-dihydroxy-6,8-dimethoxy-2-(4-methoxy-phenyl)-chromen-4-one |
| 5,7-dihydroxy-6,8-dimethoxyflavone |
| 5,7-dihydroxy-6,8,4'-trimethoxyflavone |
