Introduction：Basic information about CAS 1049743-58-9|PS 1145 dihydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | PS 1145 dihydrochloride |
|---|
| CAS Number | 1049743-58-9 | Molecular Weight | 395.670 |
|---|
| Density | / | Boiling Point | / |
|---|
| Molecular Formula | C17H13Cl3N4O | Melting Point | / |
|---|
| MSDS | ChineseUSA | Flash Point | / |
|---|
Names
| Name | N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)pyridine-3-carboxamide,dih ydrochloride |
|---|
| Synonym | More Synonyms |
|---|
PS 1145 dihydrochloride BiologicalActivity
| Description | PS-1145 (dihydrochloride) is a potent IκB kinase-2 inhibitor with an IC50 value of 88 nM. PS-1145 (dihydrochloride) inhibits activity of NF-κB by blocking IκB kinase phosphorylation in tumor-bearing rats[1]. |
|---|
| Related Catalog | Signaling Pathways >>NF-κB >>IKKResearch Areas >>Inflammation/Immunology |
|---|
| Target | IC50: 88 nM (IκB kinase-2)[1] |
|---|
| References | [1]. Cernackova A, et al. Cachexia induced by Yoshida ascites hepatoma in Wistar rats is not associated with inflammatory response in the spleen or brain. J Neuroimmunol. 2019;337:577068. |
|---|
Chemical & Physical Properties
| Molecular Formula | C17H13Cl3N4O |
|---|
| Molecular Weight | 395.670 |
|---|
| Exact Mass | 394.015503 |
|---|
| PSA | 74.16000 |
|---|
| LogP | 6.00480 |
|---|
| InChIKey | QTDCBADLGJZBHP-UHFFFAOYSA-N |
|---|
| SMILES | Cl.Cl.O=C(Nc1cc(Cl)cc2c1[nH]c1cnccc12)c1cccnc1 |
|---|
Synonyms
| N-(6-Chloro-9H-β-carbolin-8-yl)nicotinamide dihydrochloride |
| 3-Pyridinecarboxamide, N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)-, hydrochloride (1:2) |
| PS-1145 Dihydrochloride |
