CAS 101714-41-4|BiP inducer X
| Common Name | BiP inducer X | ||
|---|---|---|---|
| CAS Number | 101714-41-4 | Molecular Weight | 209.22 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 517.1±45.0 °C at 760 mmHg |
| Molecular Formula | C9H7NO3S | Melting Point | 127 °C |
| MSDS | ChineseUSA | Flash Point | 266.5±28.7 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | [2-(3,4-dihydroxyphenyl)-2-oxoethyl] thiocyanate |
|---|---|
| Synonym | More Synonyms |
BiP inducer X BiologicalActivity
| Description | BiP inducer X, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BiP inducer X preferentially induces BiP with slight inductions of GRP94, calreticulin, and C/EBP homologous protein. BiP inducer X protects neurons from ER stress[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Neurological Disease |
| In Vitro | BiP inducer X (5 μM; 0-12 hours; SK-N-SH cells) increase BiP protein[1]. The induction of BiP by BiP inducer X (BIX) is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway[1]. BiP inducer X (5 μM; 12 hours; pretreatment with SK-N-SH cells) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4[1]. |
| In Vivo | BiP inducer X administration reduces the insults due to cerebral infarction[1]. A 20 μg portion of BiP inducer X administration reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion[1]. Animal Model: Male adult ddY mice weighing 24-34 g (Japan SLC)[1] Dosage: 20 μg (2 μl) Administration: Intracerebroventricularly Result: Significantly increased the level of BiP protein 24 h after administration, confirming that administration of BIX induces BiP protein in vivo. |
| References | [1]. Kudo T, et al. A molecular chaperone inducer protects neurons from ER stress. Cell Death Differ. 2008;15(2):364-375. [2]. Yoo SA, et al. A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis. J Exp Med. 2012;209(4):871-886. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 517.1±45.0 °C at 760 mmHg |
| Melting Point | 127 °C |
| Molecular Formula | C9H7NO3S |
| Molecular Weight | 209.22 |
| Flash Point | 266.5±28.7 °C |
| Exact Mass | 209.014664 |
| PSA | 106.62000 |
| LogP | 1.53 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.665 |
| InChIKey | SVFLBLCWKKQKDW-UHFFFAOYSA-N |
| SMILES | N#CSCC(=O)c1ccc(O)c(O)c1 |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H317 |
| Precautionary Statements | P280 |
| Hazard Codes | Xn |
| RIDADR | NONH for all modes of transport |
Articles3
More Articles| Endothelial protective genes induced by statin are mimicked by ERK5 activation as triggered by a drug combination of FTI-277 and GGTI-298. Biochim. Biophys. Acta 1850 , 1415-25, (2015) Statins are potent inhibitors of cholesterol biosynthesis and are clinically beneficial in preventing cardiovascular diseases, however, the therapeutic utility of these drugs is limited by myotoxicity... | |
| In vivo efficacy of human recombinant factor IX produced by the human hepatoma cell line HuH-7. Haemophilia 21 , e317-21, (2015) Post-translational modifications of the CHO-cell-derived-recombinant human factor IX (FIX) currently used for the treatment of hemophilia B (HB) are different from plasma derived FIX. Our previous stu... | |
| PAX6 Isoforms, along with Reprogramming Factors, Differentially Regulate the Induction of Cornea-specific Genes. Sci. Rep. 6 , 20807, (2016) PAX6 is the key transcription factor involved in eye development in humans, but the differential functions of the two PAX6 isoforms, isoform-a and isoform-b, are largely unknown. To reveal their funct... |
Synonyms
| BIX |
| 1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone |
| 2-(3,4-Dihydroxyphenyl)-2-oxoethyl thiocyanate |
| 1-(3,4-Dihydroxy-phenyl)-2-thiocyanato-aethanon |
| Thiocyanicacid,3,4-dihydroxyphenacyl ester (6CI) |
| 1-(3,4-dihydroxy-phenyl)-2-thiocyanato-ethanone |
| BiP inducer X |
| Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester |
| Thiocyanic acid,2-(3,4-dihydroxyphenyl)-2-oxoethyl ester |
| Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester (9CI) |
