CAS 1508-75-4|Tropicamide

Introduction：Basic information about CAS 1508-75-4|Tropicamide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Tropicamide BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles128
8. Synonyms

Common Name	Tropicamide
CAS Number	1508-75-4	Molecular Weight	284.353
Density	1.2±0.1 g/cm3	Boiling Point	492.8±45.0 °C at 760 mmHg
Molecular Formula	C₁₇H₂₀N₂O₂	Melting Point	98 °C
MSDS	ChineseUSA	Flash Point	251.8±28.7 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	Tropicamide
Synonym	More Synonyms

Tropicamide BiologicalActivity

Description	Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist .Target: mAChRTropicamide is an antimuscarinic drug that produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops. It is used to allow better examination of the lens, vitreous humor, and retina. Due to its relatively short duration of effect (4-8 hours), it is typically used during eye examinations such as the dilated fundus examination, but it may also be used before or after eye surgery. Cycloplegic drops are often also used to treat anterior uveitis, decreasing risk of posterior synechiae and decreasing inflammation in the anterior chamber of the eye [1-3].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>mAChRSignaling Pathways >>Neuronal Signaling >>mAChRResearch Areas >>Neurological Disease
References	[1]. Lazareno, S., N.J. Buckley, and F.F. Roberts, Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells. Mol Pharmacol, 1990. 38(6): p. 805-15. [2]. Hernandez, M., et al., Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter. Br J Pharmacol, 1993. 110(4): p. 1413-20.

Description

Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist .Target: mAChRTropicamide is an antimuscarinic drug that produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops. It is used to allow better examination of the lens, vitreous humor, and retina. Due to its relatively short duration of effect (4-8 hours), it is typically used during eye examinations such as the dilated fundus examination, but it may also be used before or after eye surgery. Cycloplegic drops are often also used to treat anterior uveitis, decreasing risk of posterior synechiae and decreasing inflammation in the anterior chamber of the eye [1-3].

Related Catalog

Signaling Pathways >>GPCR/G Protein >>mAChRSignaling Pathways >>Neuronal Signaling >>mAChRResearch Areas >>Neurological Disease

References

[1]. Lazareno, S., N.J. Buckley, and F.F. Roberts, Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells. Mol Pharmacol, 1990. 38(6): p. 805-15.

[2]. Hernandez, M., et al., Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter. Br J Pharmacol, 1993. 110(4): p. 1413-20.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	492.8±45.0 °C at 760 mmHg
Melting Point	98 °C
Molecular Formula	C₁₇H₂₀N₂O₂
Molecular Weight	284.353
Flash Point	251.8±28.7 °C
Exact Mass	284.152466
PSA	53.43000
LogP	1.15
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.586
InChIKey	BGDKAVGWHJFAGW-UHFFFAOYSA-N
SMILES	CCN(Cc1ccncc1)C(=O)C(CO)c1ccccc1
Storage condition	2-8°C
Water Solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 4.3 mg/mL

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY1487860

CHEMICAL NAME :: Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-

CAS REGISTRY NUMBER :: 1508-75-4

BEILSTEIN REFERENCE NO. :: 0285563

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C17-H20-N2-O2

MOLECULAR WEIGHT :: 284.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 865 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,760,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,760,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 872 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,760,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 565 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,760,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 695 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,760,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 665 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,760,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2832 No. of Facilities: 112 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4368 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2832 No. of Facilities: 29 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 11614 (estimated) No. of Female Employees: 11545 (estimated)

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302 + H312 + H332-H315-H317-H319-H335
Precautionary Statements	P261-P280-P301 + P312 + P330-P305 + P351 + P338
Hazard Codes	Xn:Harmful
Risk Phrases	R20/21/22;R36/37/38;R42/43
Safety Phrases	S22-S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	CY1487860
HS Code	2933399090

Customs

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Synonyms

N-Ethyl-N-(g-picolyl)tropamide

8-Methyl-8-azabicyclo[3.2.1]octan-3-ol

N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide

Tropine

endo-Tropanol

TROPAN-3ALPHA-OL

3alpha-Tropanol

N-Ethyl-a-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide

8-Azabicyclo[3.2.1]octan-3-ol, 8-methyl-

N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide

N-Ethyl-N-(4-pyridylmethyl)tropamide

N-Ethyl-3-hydroxy-2-phenyl-N-(4-pyridinylmethyl)propanamide

Benzeneacetamide, N-ethyl-α-(hydroxymethyl)-N-(4-pyridinylmethyl)-

EINECS 216-140-2

Tropicamide

Mydriacyl

N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide,Ro 1-7683,Tropicamide

UNII:N0A3Z5XTC6

endo-8-Methyl-8-azabicyclo[3.2.1]octan-3-ol

tropinol

MFCD00058580

3-TROPANOL

N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide,Ro 1-7683

TROPANOL

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