CAS 538-09-0|8-Aza-bicyclo[3.2.1]octan-3-ol HCl

Introduction：Basic information about CAS 538-09-0|8-Aza-bicyclo[3.2.1]octan-3-ol HCl, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 8-Aza-bicyclo[3.2.1]octan-3-ol HCl BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	8-Aza-bicyclo[3.2.1]octan-3-ol HCl
CAS Number	538-09-0	Molecular Weight	122.164
Density	1.0±0.1 g/cm3	Boiling Point	218.2±8.0 °C at 760 mmHg
Molecular Formula	C₇H₁₃NO	Melting Point	108-110ºC
MSDS	/	Flash Point	102.2±0.0 °C

Names

Name	Nortropine
Synonym	More Synonyms

8-Aza-bicyclo[3.2.1]octan-3-ol HCl BiologicalActivity

Description	Nortropine (Nortropenol), isolated from the total alkaloids of Convolvulus subhirsutus, is an intermediate in tropine breakdown and reactions leading to succinate[1].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. Bartholomew BA, et al. Atropine Metabolism by Pseudomonas sp. Strain AT3: Evidence for Nortropine as an Intermediate in Tropine Breakdown and Reactions Leading to Succinate. Appl Environ Microbiol. 1996 Sep;62(9):3245-50. [2]. A. M. Gapparov, et al. Alkaloids of Convolvulus subhirsutus from Uzbekistan. Chemistry of Natural Compounds. 2007. 43(3):291-292.

Description

Nortropine (Nortropenol), isolated from the total alkaloids of Convolvulus subhirsutus, is an intermediate in tropine breakdown and reactions leading to succinate[1].

Related Catalog

Research Areas >>OthersSignaling Pathways >>Others >>Others

References

[1]. Bartholomew BA, et al. Atropine Metabolism by Pseudomonas sp. Strain AT3: Evidence for Nortropine as an Intermediate in Tropine Breakdown and Reactions Leading to Succinate. Appl Environ Microbiol. 1996 Sep;62(9):3245-50.

[2]. A. M. Gapparov, et al. Alkaloids of Convolvulus subhirsutus from Uzbekistan. Chemistry of Natural Compounds. 2007. 43(3):291-292.

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	218.2±8.0 °C at 760 mmHg
Melting Point	108-110ºC
Molecular Formula	C₇H₁₃NO
Molecular Weight	122.164
Flash Point	102.2±0.0 °C
Exact Mass	122.073166
PSA	40.46000
LogP	1.36
Vapour Pressure	0.1±0.5 mmHg at 25°C
Index of Refraction	1.536
InChIKey	YYMCYJLIYNNOMK-MEKDEQNOSA-N
SMILES	OC1CC2CCC(C1)N2

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RD0700000

CHEMICAL NAME :: 1-alpha-H,5-alpha-H-Nortropan-3-alpha-ol

CAS REGISTRY NUMBER :: 538-09-0

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C7-H13-N-O

MOLECULAR WEIGHT :: 127.21

WISWESSER LINE NOTATION :: T56 A AMTJ GQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1420 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 145,97,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANCPAC Annales de Chimie. (Masson et Cie, Paris, France) V.9-15, 1914-77. Volume(issue)/page/year: 7,537,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 41 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 145,97,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANCPAC Annales de Chimie. (Masson et Cie, Paris, France) V.9-15, 1914-77. Volume(issue)/page/year: 7,537,1962

Safety Information

Hazard Codes	Xi
HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

β-Phenylethyl alcohol

b-Phenylethanol

β-Phenylethanol

3a-Nortropanol

2-Hydroxyethylbenzene

(3-endo)-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride (1:1)

Phenylethyl alcohol (USP)

endo-8-azabicyclo(3.2.1)octan-3-ol hydrochloride

β-phenylethyl alcoho

8-Aza-bicyclo[3.2.1]octan-3-ol HCl

b-pea

Nortropin

(2-Hydroxyethyl)benzene

8-Azabicyclo[3.2.1]octan-3-ol

Tropigenin

nortropenol

phenylethanol

β-Phenethyl alcohol

b-Phenylethyl alcohol

(3-endo)-8-Azabicyclo[3.2.1]octan-3-olato(2-) hydrochloride (1:1)

endo-8-Azabicyclo[3.2.1]octan-3-ol

nortropan-3endo-ol

N-Demethyltropine

PEA

N-normethyltropine

Benzeneethanol

Phenyl Ethanol

Q2R

3-hydroxy-nortropan

NOR-TROPANOL

2-Phenylethanol

b-Phenethanol

8-Azabicyclo[3.2.1]octan-3-ol, (3-endo), hydrochloride (1:1)

b-Hydroxyethylbenzene

β-PEA

Tropigenine

Phenethylalcohol

Phenylethyl alcohol

β-Hydroxyethylbenzene

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