CAS 5630-53-5|Tibolone(Liviella)(Livial)
| Common Name | Tibolone(Liviella)(Livial) | ||
|---|---|---|---|
| CAS Number | 5630-53-5 | Molecular Weight | 312.446 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 447.4±45.0 °C at 760 mmHg |
| Molecular Formula | C21H28O2 | Melting Point | 169 °C |
| MSDS | ChineseUSA | Flash Point | 190.6±21.3 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | tibolone |
|---|---|
| Synonym | More Synonyms |
Tibolone(Liviella)(Livial) BiologicalActivity
| Description | Tibolone is a broad spectrum gonadal steroid agonist with progestagenic, androgenic, and estrogenic activities. Tibolone can be used for postmenopausal osteoporosis research[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>Estrogen Receptor/ERRSignaling Pathways >>Others >>Progesterone ReceptorResearch Areas >>EndocrinologySignaling Pathways >>Others >>Androgen Receptor |
| In Vivo | Tibolone (1 mg/day; oral administration; for 12 weeks) treatment enhances the osseointegration process of intramedullary titanium implants in ovariectomized rats[1]. Animal Model: Female albino Wistar rats bearing ovariectomy[1] Dosage: 1 mg/day Administration: Oral administration; daily; for 12 weeks Result: Showed a significantly higher overall bone tissue and a higher body mass density. |
| References | [1]. Dragos Apostu, et al. Tibolone, alendronate, and simvastatin enhance implant osseointegration in a preclinical in vivo model. Clin Oral Implants Res. 2020 Jul;31(7):655-668. [2]. Marcos García-Juárez, et al. Tibolone induces lordosis behavior, but not concurrent or sequential inhibition, in Sprague Dawley rats. Neurosci Lett. 2021 Apr 24;755:135916. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 447.4±45.0 °C at 760 mmHg |
| Melting Point | 169 °C |
| Molecular Formula | C21H28O2 |
| Molecular Weight | 312.446 |
| Flash Point | 190.6±21.3 °C |
| Exact Mass | 312.208923 |
| PSA | 37.30000 |
| LogP | 4.03 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.570 |
| InChIKey | WZDGZWOAQTVYBX-XOINTXKNSA-N |
| SMILES | C#CC1(O)CCC2C3C(C)CC4=C(CCC(=O)C4)C3CCC21C |
| Storage condition | 2-8°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | N |
| Risk Phrases | R51/53 |
| Safety Phrases | S22-S24/25-S61 |
| RIDADR | UN 3077 9/PG 3 |
| RTECS | RC8964020 |
Articles54
More Articles| Tibolone prevents oxidation and ameliorates cholinergic deficit induced by ozone exposure in the male rat hippocampus. Neurochem. Res. 39(9) , 1776-86, (2014) Oxidative stress is related to the development of central nervous system diseases involving memory processes. Cholinergic system and memory processes are disrupted by ozone exposure. In rats, ozone in... | |
| Effects of tibolone or continuous combined oestradiol/norethisterone acetate on glucose and insulin metabolism. Clin. Endocrinol. (Oxf.) 78(2) , 297-302, (2013) To determine the effects of tibolone or oestradiol (E(2) )/norethisterone acetate (NETA) hormone replacement therapy on glucose and insulin metabolism in postmenopausal women.Single-centre double-blin... | |
| Effects of a continuous-combined regimen of low-dose hormone therapy (oestradiol and norethindrone acetate) and tibolone on the quality of life in symptomatic postmenopausal women: a double-blind, randomised study. Maturitas 74(2) , 172-8, (2013) This study compared the effects of a continuous-combined regimen of low-dose hormone therapy (LD-HT) versus tibolone and supplemental calcium/vitamin D3 (control) on quality of life (QoL) in symptomat... |
Synonyms
| EINECS 227-069-1 |
| 17-Hydroxy-7α-methyl-19-nor-17α-pregn-5(10)-en-20-yn-3-one |
| Tibolone |
| 7a-Methyl-5,10-norethindrone |
| 7a-Methyl-17a-ethynyl-17b-hydroxy-19-norandrost-5(10)-en-3-one |
| LIVIELLA |
| 19-Norpregn-5(10)-en-20-yn-3-one, 17-hydroxy-7-methyl-, (7α,17α)- |
| Org OD 14 |
| (7α,17α)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one |
| 7a-Methyl-D5,10-norethindrone |
| (7R,8R,9S,13S,14S,17R)-17-Ethynyl-17-hydroxy-7,13-dimethyl-1,2,4,6,7,8,9,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one |
| Estr-5(10)-en-3-one, 17-ethynyl-17-hydroxy-7-methyl-, (7α,17β)- |
| Livial |
| 7a-Methyl-17a-ethynyl-17b-hydroxyestr-5(10)-en-3-one |
| MFCD00864178 |
| (7a,17a)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one |
