CAS 75-68-3|f 142b

CHEMICAL IDENTIFICATION

RTECS NUMBER :

KH7650000

CHEMICAL NAME :

Ethane, 1-chloro-1,1-difluoro-

CAS REGISTRY NUMBER :

75-68-3

BEILSTEIN REFERENCE NO. :

1731584

LAST UPDATED :

199712

DATA ITEMS CITED :

14

MOLECULAR FORMULA :

C2-H3-Cl-F2

MOLECULAR WEIGHT :

100.50

WISWESSER LINE NOTATION :

GXFF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2050 gm/m3/4H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1758 gm/m3/2H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

500 gm/m3/4H/4W-I

TOXIC EFFECTS :

Endocrine - evidence of thyroid hypofunction

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

10 pph/16H/9D-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - other changes Related to Chronic Data - death

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

1000 ppm/6H

SEX/DURATION :

female 3-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

MUTATION DATA

TYPE OF TEST :

Mutation in microorganisms

TEST SYSTEM :

Bacteria - Salmonella typhimurium

DOSE/DURATION :

50 pph/24H

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 72,15,1984 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY:TWA 1000 ppm (4170 mg/m3) JAN 1993 OEL-HUNGARY:TWA 100 mg/m3;STEL 200 mg/m3 JAN 1993 OEL-RUSSIA:STEL 3000 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82201 No. of Facilities: 11 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 357 (estimated)