CAS 2312-35-8|2-(4-(tert-Butyl)phenoxy)cyclohexyl prop-2-yn-1-yl sulfite

Introduction:Basic information about CAS 2312-35-8|2-(4-(tert-Butyl)phenoxy)cyclohexyl prop-2-yn-1-yl sulfite, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name2-(4-(tert-Butyl)phenoxy)cyclohexyl prop-2-yn-1-yl sulfite
CAS Number2312-35-8Molecular Weight350.472
Density1.2±0.1 g/cm3Boiling Point450.7±45.0 °C at 760 mmHg
Molecular FormulaC19H26O4SMelting Point/
MSDSChineseUSAFlash Point226.4±28.7 °C
Symbol
GHS05, GHS06, GHS08, GHS09
Signal WordDanger

Names

Namepropargite
SynonymMore Synonyms

BiologicalActivity

DescriptionPropargite is a pesticide used to kill mites. Propargite induces β-cell necrosis preceded by DNA damage. Propargite induces MIN6 cell death with an IC50 of 1 μM[1].
Related CatalogResearch Areas >>Infection
References

[1]. Ting Zhou, et al. A hPSC-based Platform to Discover Gene-Environment Interactions That Impact Human β-cell and Dopamine Neuron Survival. Nat Commun. 2018 Nov 16;9(1):4815.

Chemical & Physical Properties

Density1.2±0.1 g/cm3
Boiling Point450.7±45.0 °C at 760 mmHg
Molecular FormulaC19H26O4S
Molecular Weight350.472
Flash Point226.4±28.7 °C
Exact Mass350.155182
PSA63.97000
LogP4.81
Vapour Pressure0.0±1.1 mmHg at 25°C
Index of Refraction1.561
InChIKeyZYHMJXZULPZUED-UHFFFAOYSA-N
SMILESC#CCOS(=O)OC1CCCCC1Oc1ccc(C(C)(C)C)cc1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WT2900000
CHEMICAL NAME :
Sulfurous acid, 2-(p-tert-butylphenoxy)cyclohexyl-2-propynyl ester
CAS REGISTRY NUMBER :
2312-35-8
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C19-H26-O4-S
MOLECULAR WEIGHT :
350.51
WISWESSER LINE NOTATION :
L6TJ AOSO&O2UU1 BOR DX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1480 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 14,515,1969
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>940 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,719,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued. Volume(issue)/page/year: 9,119,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
780 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 16(1),45,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
10300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A589,1985 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

Safety Information

Symbol
GHS05, GHS06, GHS08, GHS09
Signal WordDanger
Hazard StatementsH315-H318-H331-H351-H410
Precautionary StatementsP261-P273-P280-P305 + P351 + P338-P311-P501
Personal Protective EquipmentEyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard CodesT:Toxic
Risk PhrasesR23;R38;R40;R41;R50/53
Safety PhrasesS26-S36/37/39-S45-S60-S61
RIDADRUN 2810
RTECSWT2900000
Packaging GroupIII
Hazard Class9
HS Code2920909014

Customs

HS Code2920909014
Summary2920909014 2-(4-(tert-butyl)phenoxy)cyclohexyl prop-2-yn-1-yl sulfite。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

Articles24

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Permeation of Comite through protective gloves.

J. Hazard. Mater. 137(1) , 165-71, (2006)

The goal of the study was to assess how protective disposable (Safeskin) and chemical protective (Sol-Vex) nitrile gloves were against Comite emulsifiable concentrate formulation containing propargite...

Genotoxic effects of the pesticides Rubigan, Omite and Rovral in root-meristem cells of Crepis capillaris L.

Mutat. Res. 652(2) , 191-7, (2008)

Three pesticides have been studied for their genotoxicity by the use of assays in the plant Crepis capillaris, aimed at measuring chromosomal aberrations, micronuclei and sister chromosome exchange (S...

Toxicity of three acaricides to Tetranychus urticae (Tetranychidae: Acari) and Orius insidiosus (Anthocoridae: Hemiptera).

J. Econ. Entomol. 99(1) , 54-9, (2006)

Management for twospotted spider mite, Tetranychus urticae Koch, populations in peanut, Arachis hypogaea L., relies on acaricides. The outcomes of acaricide applications are most predictable when comp...

Synonyms

Propargite
d014
do14
Propargiet
Sulfurous acid, 2-[4-(1,1-dimethylethyl)phenoxy]cyclohexyl 2-propynyl ester
(1RS,2RS
comite
Sulfurous Acid 2-[4-(1,1-Dimethylethyl)phenoxy]cyclohexyl 2-Propynyl Ester
EINECS 219-006-1
2-[4-(2-Methyl-2-propanyl)phenoxy]cyclohexyl 2-propyn-1-yl sulfite
Omit
BPPS
MFCD00072448
Omite
progi
1RS,2SR)-2-(4-tert-butylphenoxy)cyclohexyl prop-2-ynyl sulfite
2-(4-tert-Butylphenoxy)cyclohexyl 2-propynyl sulfite
2-(4-tert-Butylphenoxy)cyclohexyl prop-2-yn-1-yl sulfite
PROP 57
omait
2-(4-tert-Butylphenoxy)cyclohexyl-prop-2-in-1-ylsulfit
Sulfurous Acid 2-(p-tert-Butylphenoxy)cyclohexyl 2-Propynyl Ester
(1Ξ,2Ξ)-2-(4-tert-butylphenoxy)cyclohexyl prop-2-yn-1-yl sulfite
Propargil
2-[4-(1,1-dimethylethyl)phenoxy]cyclohexyl 2-propyn-1-yl sulfite
Sulfurous acid, 2-[4-(1,1-dimethylethyl)phenoxy]cyclohexyl 2-propyn-1-yl ester
2-(4-(tert-Butyl)phenoxy)cyclohexyl prop-2-yn-1-yl sulfite
RETADOR
CAS 431-89-0|Heptafluoropropane
CAS 34014-18-1|Tebuthiuron
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