CAS 104632-26-0|Pramipexole

Introduction：Basic information about CAS 104632-26-0|Pramipexole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Pramipexole BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Pramipexole
CAS Number	104632-26-0	Molecular Weight	211.327
Density	1.2±0.1 g/cm3	Boiling Point	378.0±42.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₇N₃S	Melting Point	288-290°C
MSDS	/	Flash Point	182.4±27.9 °C

Names

Name	pramipexole
Synonym	More Synonyms

Pramipexole BiologicalActivity

Description	Pramipexole is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS).Target: Dopamine Receptor Pramipexole also possesses low/insignificant affinity (500-10,000 nM) for the 5-HT1A, 5-HT1B, 5-HT1D, and α2-adrenergic receptors. It has negligible affinity (>10,000 nM) for the D1, D5, 5-HT2, α1-adrenergic, β-adrenergic, H1, and mACh receptors. All sites assayed were done using human tissues. While pramipexole is used clinically, its D3-preferring receptor binding profile has made it a popular tool compound for preclinical research. Pramipexole has been used (in combination with D2- and or D3-preferring antagonists) to interrogate the role of D3 receptor function in rodent models and tasks for neuropsychiatric disorders [1-3].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease
References	[1]. Kvernmo, T., S. Hartter, and E. Burger, A review of the receptor-binding and pharmacokinetic properties of dopamine agonists. Clin Ther, 2006. 28(8): p. 1065-78. [2]. Millan, M.J., et al., Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J Pharmacol Exp Ther, 2002. 3 [3]. Weber, M., et al., Heritable strain differences in sensitivity to the startle gating-disruptive effects of D2 but not D3 receptor stimulation. Behav Pharmacol, 2008. 19(8): p. 786-95.

Description

Pramipexole is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS).Target: Dopamine Receptor Pramipexole also possesses low/insignificant affinity (500-10,000 nM) for the 5-HT1A, 5-HT1B, 5-HT1D, and α2-adrenergic receptors. It has negligible affinity (>10,000 nM) for the D1, D5, 5-HT2, α1-adrenergic, β-adrenergic, H1, and mACh receptors. All sites assayed were done using human tissues. While pramipexole is used clinically, its D3-preferring receptor binding profile has made it a popular tool compound for preclinical research. Pramipexole has been used (in combination with D2- and or D3-preferring antagonists) to interrogate the role of D3 receptor function in rodent models and tasks for neuropsychiatric disorders [1-3].

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease

References

[1]. Kvernmo, T., S. Hartter, and E. Burger, A review of the receptor-binding and pharmacokinetic properties of dopamine agonists. Clin Ther, 2006. 28(8): p. 1065-78.

[2]. Millan, M.J., et al., Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J Pharmacol Exp Ther, 2002. 3

[3]. Weber, M., et al., Heritable strain differences in sensitivity to the startle gating-disruptive effects of D2 but not D3 receptor stimulation. Behav Pharmacol, 2008. 19(8): p. 786-95.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	378.0±42.0 °C at 760 mmHg
Melting Point	288-290°C
Molecular Formula	C₁₀H₁₇N₃S
Molecular Weight	211.327
Flash Point	182.4±27.9 °C
Exact Mass	211.114319
PSA	79.18000
LogP	1.42
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.583
InChIKey	FASDKYOPVNHBLU-ZETCQYMHSA-N
SMILES	CCCNC1CCc2nc(N)sc2C1
Storage condition	-20°C Freezer

Safety Information

Hazard Codes	Xi
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26-S36
WGK Germany	3
HS Code	2934999090

Customs

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

N~6~-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine dihydrochloride

n'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine

(Pramipexole )

(S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole

(S)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine

(S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine

[(6S)-2-Amino(4,5,6,7-tetrahydrobenzothiazol-6-yl)]propylamine

(S)-Pramipexole

2,6-BENZOTHIAZOLEDIAMINE,4,5,6,7-TETRAHYDRO-N6-PROPYL-, (6S)-

U 98528E

MFCD00869076

(6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine

Pramipexole

(S)-2-AMINO-6-(PROPYLAMINO)-4,5,6,7-TETRAHYDROBENZOTHIAZOL TETRAHYDROBENZOTHIAZOL

T56 BN DSJ CZ GM3 &&S Form

(s)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole

Pramipexole(S)-2-Amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole

2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N-propyl-, (6S)-

(S)-N6-Propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine

(+)-pramipexole

pramipexol

(6S)-N-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine

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