CAS 68157-60-8|forchlorfenuron
| Common Name | forchlorfenuron | ||
|---|---|---|---|
| CAS Number | 68157-60-8 | Molecular Weight | 247.680 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 426.5±55.0 °C at 760 mmHg |
| Molecular Formula | C12H10ClN3O | Melting Point | 170-172°C |
| MSDS | ChineseUSA | Flash Point | 211.7±31.5 °C |
| Symbol | GHS08, GHS09 | Signal Word | Warning |
Names
| Name | forchlorfenuron |
|---|---|
| Synonym | More Synonyms |
forchlorfenuron BiologicalActivity
| Description | Forchlorfenuron is plant growth regulator and cytokinin; can be used to increase fruit size of fruits, such as kiwi fruit and grapes. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Others |
| In Vitro | Forchlorfenuron is a plant growth regulator, applied extensively to increase kiwifruit size and weight. Cytotoxicity of forchlorfenuron and its metabolites are tested through Sulforhodamine B assays against CHO cells. Forchlorfenuron exhibits significant cytotoxicity against CHO cells with an IC50 of 12.12±2.14 μM[1]. The half-lives offorchlorfenuron were 15.8-23.0 days, the final residues of forchlorfenuron in pulp were all ≤0.002 mg/kg, and most of the residues were concentrated in the peel. The risk assessment revealed that no significant potential health risk would be induced by forchlorfenuron in citrus fruits. Therefore, it could be safe to apply forchlorfenuron in citrus fruits[2]. |
| Cell Assay | CHO cells are cultured in high-glucose DMEM medium. Forchlorfenuron and its kiwifruit metabolites are dissolved in DMSO and diluted in culture media. Cells are seeded in a 96-well flat microtiter plate for 24 h and are then incubated for an additional 48 h with various concentrations of the compounds. Next, cells are fixed with 10% trichloroacetic acid and incubated for 60 min at 4 °C. The supernatant is discarded, then the plates are washed. Using 0.4% SRB solution dissolved in 1% acetic acid, the cell layer is strained, then the plates are incubated for 20 min at room temperature. The stained cells is solubilized in 10 mM un-buffered Tris base and optical density (OD) is measured at 560 nm[1]. |
| References | [1]. Zhang Z, et al. Identification, synthesis, and safety assessment of forchlorfenuron (1-(2-chloro-4-pyridyl)-3-phenylurea) and its metabolites in kiwifruits. J Agric Food Chem. 2015 Mar 25;63(11):3059-66. [2]. Chen W, et al. Dissipation and residue of forchlorfenuron in citrus fruits. Bull Environ Contam Toxicol. 2013 Jun;90(6):756-60. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 426.5±55.0 °C at 760 mmHg |
| Melting Point | 170-172°C |
| Molecular Formula | C12H10ClN3O |
| Molecular Weight | 247.680 |
| Flash Point | 211.7±31.5 °C |
| Exact Mass | 247.051239 |
| PSA | 54.02000 |
| LogP | 3.83 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.629 |
| InChIKey | GPXLRLUVLMHHIK-UHFFFAOYSA-N |
| SMILES | O=C(Nc1ccccc1)Nc1ccnc(Cl)c1 |
| Storage condition | 2-8°C |
Safety Information
| Symbol | GHS08, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H351-H411 |
| Precautionary Statements | P273-P281 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37 |
| Safety Phrases | S26-S36 |
| RIDADR | UN3077 9/PG 3 |
| WGK Germany | 3 |
| RTECS | YS7182500 |
| HS Code | 2933399090 |
Customs
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles29
More Articles| Septins arrange F-actin-containing fibers on the Chlamydia trachomatis inclusion and are required for normal release of the inclusion by extrusion. MBio 5(5) , e01802-14, (2014) Chlamydia trachomatis is an obligate intracellular human pathogen that grows inside a membranous, cytosolic vacuole termed an inclusion. Septins are a group of 13 GTP-binding proteins that assemble in... | |
| Determination of forchlorfenuron in fruits by solid phase or QuECHERS extraction and LC-UV or LC/MS/MS. J. AOAC Int. 97(3) , 938-41, (2014) Forchlorfenuron, N-(2-chloro-4-pyridinyl)-N'-phenylurea, is a plant growth regulator used to increase the size of kiwifruit, apples, table grapes, and peaches and to promote increased yields of potato... | |
| Application of plant growth regulators mitigates chlorotic foliar injury by the black pecan aphid (Hemiptera: Aphididae). Pest Manag. Sci. 66(11) , 1236-42, (2010) Black pecan aphid, Melanocallis caryaefoliae (Davis) (Hemiptera: Aphididae), feeding elicits localized chlorotic injury to pecan foliage [Carya illinoinensis (Wangenh.) K Koch] and apparent accelerati... |
Synonyms
| N-(2-chloropyridin-4-yl)-N’-phenylurea |
| KT-30 |
| N-(2-chloro-4-pyridinyl)-N’-phenylurea |
| 4pu30 |
| CN-11-3183 |
| CPPU |
| fulmet |
| 1-(2-Chloro-4-Pyridyl)-3-Phenylurea |
| MFCD00059898 |
| SITOFEX |
| v3183 |
| cn11-3138 |
| 4-CPPU |
