CAS 52811-37-7|Cearoin
Introduction：Basic information about CAS 52811-37-7|Cearoin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cearoin | ||
|---|---|---|---|
| CAS Number | 52811-37-7 | Molecular Weight | 244.24300 |
| Density | 1.296g/cm3 | Boiling Point | 443.8ºC at 760 mmHg |
| Molecular Formula | C14H12O4 | Melting Point | / |
| MSDS | / | Flash Point | 171.7ºC |
Names
| Name | (2,5-dihydroxy-4-methoxyphenyl)-phenylmethanone |
|---|
Cearoin BiologicalActivity
| Description | Cearoin, isolated from Dalbergia odorifera, increases autophagy and apoptosis through the production of ROS and the activation of ERK[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Protein Tyrosine Kinase/RTK >>ROSSignaling Pathways >>Autophagy >>AutophagySignaling Pathways >>MAPK/ERK Pathway >>ERKSignaling Pathways >>Stem Cell/Wnt >>ERK |
| Target | ERK ROS Autophagy Apoptosis |
| In Vitro | Cearoin (10-80 μM) induces cell death in a dose-dependent manner[1]. Cearoin (10-80 μM) increases the phosporylation of ERK in SH-SY5Y cells[1]. Cearoin (5-80 μM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process[1]. Cell Viability Assay[1] Cell Line: Human neuroblastoma SH-SY5Y cells Concentration: 0, 1, 5, 10, 20, 40, or 80 μM Incubation Time: 6 or 12 hours Result: Significantly decreased cell viability from 10 μM in a dose-dependent manner. Treatment with 40 μM for 12 h induced about 50% loss in cell viability in SH-SY5Y cells. Western Blot Analysis[1] Cell Line: Human neuroblastoma SH-SY5Y cells Concentration: 0, 5, 10, 20, 40, or 80 μM Incubation Time: 12 hours Result: Increased ERK phosphorylation in a dose-dependent manner, whereas it did not alter JNK phosphorylation. Induced the formation of LC3B-II in a dose dependent manner. |
| References | [1]. Tonking Bastola, et al. Cearoin Induces Autophagy, ERK Activation and Apoptosis via ROS Generation in SH-SY5Y Neuroblastoma Cells. Molecules. 2017 Feb 6;22(2):242. |
Chemical & Physical Properties
| Density | 1.296g/cm3 |
|---|---|
| Boiling Point | 443.8ºC at 760 mmHg |
| Molecular Formula | C14H12O4 |
| Molecular Weight | 244.24300 |
| Flash Point | 171.7ºC |
| Exact Mass | 244.07400 |
| PSA | 66.76000 |
| LogP | 2.33740 |
| Index of Refraction | 1.623 |
| InChIKey | NFJVELXCUBWAFL-UHFFFAOYSA-N |
| SMILES | COc1cc(O)c(C(=O)c2ccccc2)cc1O |
Safety Information
| HS Code | 2914509090 |
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Customs
| HS Code | 2914509090 |
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| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
