Introduction：Basic information about CAS 885434-70-8|HJC 0350, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | HJC 0350 |
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| CAS Number | 885434-70-8 | Molecular Weight | 277.38200 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C15H19NO2S | Melting Point | / |
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| MSDS | USA | Flash Point | / |
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Names
| Name | 2,4-dimethyl-1-(2,4,6-trimethyl-benzenesulfonyl)-1H-pyrrole |
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| Synonym | More Synonyms |
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HJC 0350 BiologicalActivity
| Description | HJC0350 is a potent and specific EPAC2 antagonist with an IC50 of 0.3 µM. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Cancer |
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| Target | IC50: 0.3 µM (EPAC2)[1] |
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| In Vitro | HJC0350 has an apparent IC50 value of 0.3 µM for competing with 8-NBD-cAMP binding of EPAC2, and is about 133-fold more potent than cAMP. HJC0350 is found not to inhibit EPAC1-mediated Rap1-GDP exchange activity at 25 µM in the presence of equal concentration of cAMP, indicating that it is EPAC2-specific antagonists. Pretreatment of HEK293/EPAC2-FL cells with 10 µM HJC0350 fully blocks the 007-AM induced decrease of FRET[1]. |
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| References | [1]. Chen H, et al. Identification and characterization of small molecules as potent and specific EPAC2 antagonists. J Med Chem. 2013 Feb 14;56(3):952-62. |
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Chemical & Physical Properties
| Molecular Formula | C15H19NO2S |
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| Molecular Weight | 277.38200 |
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| Exact Mass | 277.11400 |
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| PSA | 47.45000 |
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| LogP | 4.34790 |
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| InChIKey | AFZWZVLPIMHLSE-UHFFFAOYSA-N |
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| SMILES | Cc1cc(C)c(S(=O)(=O)n2cc(C)cc2C)c(C)c1 |
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| Storage condition | -20℃ |
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Safety Information
| Hazard Codes | N |
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| RIDADR | NONH for all modes of transport |
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Synonyms
