CAS 6271-21-2|Dihydrolycorine
Introduction：Basic information about CAS 6271-21-2|Dihydrolycorine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dihydrolycorine | ||
|---|---|---|---|
| CAS Number | 6271-21-2 | Molecular Weight | 289.326 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 460.5±45.0 °C at 760 mmHg |
| Molecular Formula | C16H19NO4 | Melting Point | 247℃ |
| MSDS | / | Flash Point | 232.3±28.7 °C |
Names
| Name | α-dihydrolycorine |
|---|---|
| Synonym | More Synonyms |
Dihydrolycorine BiologicalActivity
| Description | Dihydrolycorine is isolated from Lycoris radiate Herb with antihypertensive and neuroprotective activities[1]. Dihydrolycorine is an inhibitor of protein synthesis in eukarytic cells by inhibiting the peptide bone formation step[2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
| Target | Protein synthesis[2] |
| In Vivo | Dihydrolycorine reduces infarct size, cerebral edema, and myeloperoxidase activity in a rat model of focal cerebral ischemia-reperfusion injury when administered following reperfusion[1]. Dihydrolycorine inhibits methoxamine-induced contraction of isolated rabbit aortic rings and rat anococcygeus muscle with pA2 values of 5.93 and 6.35, respectively[3]. |
| References | [1]. JIANG Shi-qin, et al. Therapeutic Effects of Dihydrolycorine on Focal Cerebral Ischemia-reperfusion Injury in Rats. 《Journal of Yunyang Medical College》 2009-05 [2]. Jimenez A, et al. Inhibitors of protein synthesis in eukarytic cells. Comparative effects of some amaryllidaceae alkaloids. Biochim Biophys Acta. 1976 Mar 17;425(3):342-8. [3]. Chen BY, et al. [Hypotensive effect of dihydrolycorine]. Zhongguo Yao Li Xue Bao. 1993 Jan;14(1):45-9. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 460.5±45.0 °C at 760 mmHg |
| Melting Point | 247℃ |
| Molecular Formula | C16H19NO4 |
| Molecular Weight | 289.326 |
| Flash Point | 232.3±28.7 °C |
| Exact Mass | 289.131409 |
| PSA | 62.16000 |
| LogP | 0.85 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.701 |
| InChIKey | VJILFEGOWCJNIK-MGRBZGILSA-N |
| SMILES | OC1CC2CCN3Cc4cc5c(cc4C(C1O)C23)OCO5 |
Synonyms
| (1S,2S,3aR,12bS,12cR)-2,3,3a,4,5,7,12b,12c-Octahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol |
| Dihydrolycorine |
| 1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,3,3a,4,5,7,12b,12c-octahydro-, (1S,2S,3aR,12bS,12cR)- |
| ihydrolycorine |
