CAS 882664-74-6|Polygalasaponin F
Introduction：Basic information about CAS 882664-74-6|Polygalasaponin F, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Polygalasaponin F | ||
|---|---|---|---|
| CAS Number | 882664-74-6 | Molecular Weight | 1091.236 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C53H86O23 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | 3-O-β-D-galactopyranosylbayogenin 28-O-[β-D-xylopyranosyl-(1->4)-α-L-rhamnopyranosyl-(1->2)-β-D-glucopyranosyl] ester |
|---|---|
| Synonym | More Synonyms |
Polygalasaponin F BiologicalActivity
| Description | Polygalasaponin F, an oleanane-type triterpenoid saponin extracted from Polygala japonica, decreases the release of the inflammatory cytokine tumor necrosis factor a (TNFa). Polygalasaponin F reduces neuroinflammatory cytokine secretion through the regulation of the TLR4-PI3K/AKT-NF-kB signaling pathway [1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Toll-like Receptor (TLR)Signaling Pathways >>PI3K/Akt/mTOR >>PI3KSignaling Pathways >>PI3K/Akt/mTOR >>AktResearch Areas >>Inflammation/Immunology |
| Target | TLR4 PI3K Akt NF-κB |
| References | [1]. Yan WF , et al. The molecular mechanism of polygalasaponin F-mediated decreases in TNFα: emphasizing the role of the TLR4-PI3K/AKT-NF-κB pathway. J Asian Nat Prod Res. 2015;17(6):662-70. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C53H86O23 |
| Molecular Weight | 1091.236 |
| Exact Mass | 1090.556030 |
| PSA | 374.13000 |
| LogP | 2.32 |
| Index of Refraction | 1.640 |
| InChIKey | VRDCOPNSCZLBLD-JKVIPCSCSA-N |
| SMILES | CC1OC(OC2C(OC(=O)C34CCC(C)(C)CC3C3=CCC5C6(C)CC(O)C(OC7OC(CO)C(O)C(O)C7O)C(C)(CO)C6CCC5(C)C3(C)CC4)OC(CO)C(O)C2O)C(O)C(O)C1OC1OCC(O)C(O)C1O |
Synonyms
| β-D-Xylopyranosyl-(1->4)-6-deoxy-α-L-mannopyranosyl-(1->2)-1-O-[(2β,3β)-3-(β-D-glucopyranosyloxy)-2,23-dihydroxy-28-oxoolean-12-en-28-yl]-β-D-glucopyranose |
| Polygalasaponin F |
| POLYGALASAPONIN F (REFERENCE GRADE) |
| 3-O--D-galactopyranosylbayogenin 28-O-[-D-xylopyranosyl-(1->4)--L-rhamnopyranosyl-(1->2)--D-glucopyranosyl] ester |
| Polygalasaponin-F |
| β-D-Glucopyranose, O-β-D-xylopyranosyl-(1->4)-O-6-deoxy-α-L-mannopyranosyl-(1->2)-1-O-[(2β,3β)-3-(β-D-glucopyranosyloxy)-2,23-dihydroxy-28-oxoolean-12-en-28-yl]- |
| PolygalasaponinF |
