Introduction：Basic information about CAS 23720-80-1|Nardosinone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Nardosinone |
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| CAS Number | 23720-80-1 | Molecular Weight | 250.333 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 330.2±32.0 °C at 760 mmHg |
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| Molecular Formula | C15H22O3 | Melting Point | 108-110℃ |
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| MSDS | / | Flash Point | 142.0±25.2 °C |
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Names
| Name | nardosinone |
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| Synonym | More Synonyms |
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Nardosinone BiologicalActivity
| Description | Nardosinone, isolated from Nardostachys chinensis, is the first enhancer of the neuritogenic action of dbcAMP and staurosporine. Nardosinone may become a useful pharmacological tool for studying the mechanism of action of not only nerve growth factor (NGF) but also both the neuritogenic substances[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| In Vitro | Nardosinone (0.1-100 microM) enhanced dibutyryl cyclic AMP (dbcAMP, 0.3 mM)- and staurosporine (10 nM)-induced neurite outgrowth from PC12D cells in a concentration-dependent manner. Nardosinone enhances a downstream step of MAP kinase in the MAP kinase-dependent signaling pathway[1]. |
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| References | [1]. Li P, et al. Nardosinone, the first enhancer of neurite outgrowth-promoting activity of staurosporine and dibutyryl cyclic AMP in PC12D cells.Brain Res Dev Brain Res. 2003 Nov 12;145(2):177-83. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 330.2±32.0 °C at 760 mmHg |
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| Melting Point | 108-110℃ |
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| Molecular Formula | C15H22O3 |
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| Molecular Weight | 250.333 |
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| Flash Point | 142.0±25.2 °C |
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| Exact Mass | 250.156891 |
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| PSA | 35.53000 |
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| LogP | 3.04 |
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| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
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| Index of Refraction | 1.522 |
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| InChIKey | KXGHHSIMRWPVQM-JWFUOXDNSA-N |
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| SMILES | CC1CCC=C2C(=O)CC3OOC(C)(C)C3C21C |
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| Storage condition | 2-8C |
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Safety Information
Synonyms
| Nardosinone |
| 5H-Naphtho[2,1-c][1,2]dioxol-5-one, 1,3a,4,7,8,9,9a,9b-octahydro-1,1,9,9a-tetramethyl-, (3aR,9R,9aR,9bS)- |
| 5H-Naphtho[2,1-c][1,2]dioxol-5-one,1,3a,4,7,8,9,9a,9b-octahydro-1,1,9,9a-tetramethyl-, (3aR,9R,9aR,9bS)- |
| (3aR,9R,9aR,9bS)-1,1,9,9a-Tetramethyl-1,3a,4,7,8,9,9a,9b-octahydro-5H-naphtho[2,1-c][1,2]dioxol-5-one |
