Introduction：Basic information about CAS 886047-22-9|LY 2119620, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | LY 2119620 |
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| CAS Number | 886047-22-9 | Molecular Weight | 437.94400 |
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| Density | 1.46±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C19H24ClN5O3S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]- |
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| Synonym | More Synonyms |
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LY 2119620 BiologicalActivity
| Description | LY2119620 is a high-affinity muscarinic M2/M4 receptor agonist. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>mAChRSignaling Pathways >>Neuronal Signaling >>mAChRResearch Areas >>Neurological Disease |
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| Target | M2/M4 receptor[1] |
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| In Vitro | LY2119620 shows a modest allosteric agonism of 23.2±2.18% and 16.8±5.01% at the M2 and M4 receptors, respectively. Minimal allosteric agonism (<20%) is observed for LY2119620 at the M1, M3, and M5 receptors. The variable KB of LY2119620 for the allosteric binding site on the unoccupied receptor is found to be consistently about 1.9 to 3.4 µM. Results show a Bmax increase at the M2 receptor from 793±1.95 fmol/mg to 2850±162 fmol/mg upon addition of 10 µM LY2119620, and about a 5-fold increase in Bmax at the M4 receptor, 284±18.3 fmol/mg to 1340±42.2 fmol/mg[1]. |
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| Kinase Assay | [3H]LY2119620 equilibrium binding is achieved by incubating 15 µg membranes, orthosteric ligand (100 µM), and various concentrations of [3H]LY2119620 (0.2 to 60 nM) for 1 hour at 25°C. The specific binding versus time data are fit to a one-site specific binding model, and the Bmax and Kd for the allosteric molecule are calculated for each orthosteric ligand[1]. |
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| References | [1]. Croy CH, et al. Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M(2) and M(4) receptors. Mol Pharmacol. 2014 Jul;86(1):106-15. |
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Chemical & Physical Properties
| Density | 1.46±0.1 g/cm3 |
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| Molecular Formula | C19H24ClN5O3S |
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| Molecular Weight | 437.94400 |
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| Exact Mass | 437.12900 |
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| PSA | 129.03000 |
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| LogP | 2.73320 |
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| InChIKey | TYTGOXSAAQWLPJ-UHFFFAOYSA-N |
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| SMILES | Cc1c(Cl)c(OCC(=O)N2CCN(C)CC2)nc2sc(C(=O)NC3CC3)c(N)c12 |
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| Storage condition | -20℃ |
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| Water Solubility | Slightly soluble (2.5 g/L) (25 ºC) |
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Synonyms
| ly2119620 |
| 3-Amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide |
