CAS 153439-40-8|Fexofenadine hydrochloride

Introduction：Basic information about CAS 153439-40-8|Fexofenadine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Fexofenadine hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles12
6. Synonyms

Common Name	Fexofenadine hydrochloride
CAS Number	153439-40-8	Molecular Weight	538.117
Density	/	Boiling Point	/
Molecular Formula	C₃₂H₄₀ClNO₄	Melting Point	148-150oC
MSDS	USA	Flash Point	/

Names

Name	Fexofenadine Hydrochloride
Synonym	More Synonyms

Fexofenadine hydrochloride BiologicalActivity

Description	Fexofenadine is a third-generation antihistamine pharmaceutical drug used in the treatment of allergy symptoms, such as hay fever, nasal congestion, and urticaria.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Histamine ReceptorSignaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>Neurological Disease
References	[1]. Bachert C, et al. A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis. Clin Ther 31 (5): 921-44. [2]. Compalati E, et al. Systematic review on the efficacy of fexofenadine in seasonal allergic rhinitis: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials.". International Archives of Allergy and Immunology 156 (1): 1-15.

Description

Fexofenadine is a third-generation antihistamine pharmaceutical drug used in the treatment of allergy symptoms, such as hay fever, nasal congestion, and urticaria.

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Histamine ReceptorSignaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>Neurological Disease

References

[1]. Bachert C, et al. A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis. Clin Ther 31 (5): 921-44.

[2]. Compalati E, et al. Systematic review on the efficacy of fexofenadine in seasonal allergic rhinitis: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials.". International Archives of Allergy and Immunology 156 (1): 1-15.

Chemical & Physical Properties

Melting Point	148-150oC
Molecular Formula	C₃₂H₄₀ClNO₄
Molecular Weight	538.117
Exact Mass	537.264587
PSA	81.00000
LogP	6.25040
InChIKey	RRJFVPUCXDGFJB-UHFFFAOYSA-N
SMILES	CC(C)(C(=O)O)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1.Cl
Storage condition	−20°C

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport

Articles12

Histamine inhibits differentiation of skin fibroblasts into myofibroblasts.

Biochem. Biophys. Res. Commun. 463 , 434-9, (2015)

Histamine and TGF-β, major mediators secreted by mast cells, are involved in skin inflammation and play critical roles in the pathogenesis of systemic sclerosis. However, the roles of signaling mechan...

Probiotic properties of lactic acid bacteria isolated from water-buffalo mozzarella cheese.

Probiotics Antimicrob Proteins 6 , 141-56, (2014)

This study evaluated the probiotic properties (stability at different pH values and bile salt concentration, auto-aggregation and co-aggregation, survival in the presence of antibiotics and commercial...

Substrate- and dose-dependent drug interactions with grapefruit juice caused by multiple binding sites on OATP2B1.

Pharm. Res. 31(8) , 2035-43, (2014)

OATP2B1-mediated grapefruit juice (GFJ)-drug interactions are substrate-dependent; for example, GFJ ingestion significantly reduces bioavailability of fexofenadine, but not pravastatin. In the present...

Synonyms

2-[4-(1-Hydroxy-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butyl)phenyl]-2-methylpropansäurehydrochlorid

Fexofenidine hydrochloride MDL 16455 hydrochloride Terfenidine carboxylate hydrochloride

Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-, hydrochloride (1:1)

Fexofenadine HCl

Fexofenadine hydrochloride

benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-, hydrochloride

Fexofenidine hydrochloride,MDL 16455 hydrochloride,Terfenidine carboxylate hydrochloride

2-[4-(1-Hydroxy-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butyl)phenyl]-2-methylpropanoic acid hydrochloride (1:1)

acide 2-[4-(1-hydroxy-4-{4-[hydroxy(diphényl)méthyl]pipéridin-1-yl}butyl)phényl]-2-méthylpropanoïque chlorhydrate

MFCD08064193

UNII:2S068B75ZU

2-[4-(1-hydroxy-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butyl)phenyl]-2-methylpropanoic acid hydrochloride

2-[4-(1-Hydroxy-4-{4-[hydroxy(diphenyl)methyl]-1-piperidinyl}butyl)phenyl]-2-methylpropanoic acid hydrochloride (1:1)

benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-a,a-dimethyl-, hydrochloride (1:1)

Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-, hydrochloride

Fexofenadine (hydrochloride)

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