Introduction：Basic information about CAS 1357302-64-7|OG-L002, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | OG-L002 |
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| CAS Number | 1357302-64-7 | Molecular Weight | 225.286 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 416.7±45.0 °C at 760 mmHg |
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| Molecular Formula | C15H15NO | Melting Point | / |
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| MSDS | / | Flash Point | 205.8±28.7 °C |
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Names
| Name | [1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]- |
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| Synonym | More Synonyms |
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OG-L002 BiologicalActivity
| Description | OG-L002 is a potent and highly selective LSD1 inhibitor with an IC50 of 0.02 μM. OG-L002 is a potent monoamine oxidases (MAO) inhibitor with IC50s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 potently inhibits the expression of HSV IEgenes[1]. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>HSVResearch Areas >>InfectionSignaling Pathways >>Epigenetics >>Histone DemethylaseSignaling Pathways >>Neuronal Signaling >>Monoamine Oxidase |
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| Target | IC50: 0.02 μM (LSD1), 1.38 μM (MAO-A), 0.72 μM (MAO-B), HSV IE[1] |
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| In Vitro | OG-L002 inhibits viral IE gene expression in both cells with a significantly reduced IC50 (IC50: ~10 µM in HeLa cells; IC50: ~3 µM in HFF cells) relative to the control MAOI TCP (IC50: ~1 mM)[1]. |
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| In Vivo | OG-L002 (i.p.; 6-40 mg/kg; daily; for 7 days) reduces the levels of detectable viral genomes in the ganglia in a dose-dependent manner at both 3 and 5 days postinfection[1]. Animal Model: 4-week-old BALB/c female mice[1] Dosage: 6, 20, 40 mg/kg Administration: Intraperitoneal; daily; for 7 days Result: Reduced the levels of detectable viral genomes in the ganglia in a dose-dependent manner at both 3 and 5 days postinfection. |
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| References | [1]. Liang Y, et al. A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. mBio. 2013 Feb 5;4(1):e00558-12. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 416.7±45.0 °C at 760 mmHg |
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| Molecular Formula | C15H15NO |
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| Molecular Weight | 225.286 |
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| Flash Point | 205.8±28.7 °C |
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| Exact Mass | 225.115356 |
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| PSA | 46.25000 |
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| LogP | 2.27 |
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| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
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| Index of Refraction | 1.644 |
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| InChIKey | DSOJSZXQRJGBCW-CABCVRRESA-N |
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| SMILES | NC1CC1c1ccc(-c2cccc(O)c2)cc1 |
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| Storage condition | -20℃ |
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| Water Solubility | Very slightly soluble (0.22 g/L) (25 ºC) |
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Synonyms
| 4'-[(1R,2S)-2-Aminocyclopropyl]-3-biphenylol |
| [1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]- |
| 4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-ol |
| OG-L002 |
