CAS 811803-05-1|Apatinib
Introduction：Basic information about CAS 811803-05-1|Apatinib, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Apatinib | ||
|---|---|---|---|
| CAS Number | 811803-05-1 | Molecular Weight | 397.472 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 578.2±50.0 °C at 760 mmHg |
| Molecular Formula | C24H23N5O | Melting Point | / |
| MSDS | / | Flash Point | 303.5±30.1 °C |
Names
| Name | 3-Pyridinecarboxamide, N-[4-(1-cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]- |
|---|---|
| Synonym | More Synonyms |
Apatinib BiologicalActivity
| Description | Apatinib free base (YN968D1 free base) is an orally bioavailable tyrosine kinase inhibitor, which selectively targets VEGFR-2 (IC50=1 nM). Apatinib free base (YN968D1 free base) is an anti-angiogenic drug for the treatment of advanced or metastatic gastric cancer. Apatinib free base (YN968D1 free base) potently inhibits Ret, c-Kit and c-Src with IC50s of 13, 429 and 530 nM, respectively. It also inhibits cellular phosphorylation of VEGFR-2, c-kit and PDGFRβ[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Protein Tyrosine Kinase/RTK >>SrcSignaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Protein Tyrosine Kinase/RTK >>VEGFRSignaling Pathways >>Protein Tyrosine Kinase/RTK >>c-Kit |
| Target | IC50: 1 nM (VEGFR-2), 13 nM (Ret), 429 nM (c-Kit), 530 nM (c-Src)[3] |
| References | [1]. Roviello G, et al. Apatinib: A novel receptor tyrosine kinase inhibitor for the treatment of gastric cancer. Cancer Lett. 2016 Mar 28;372(2):187-91. [2]. Scott LJ. Apatinib: A Review in Advanced Gastric Cancer and Other Advanced Cancers. Drugs. 2018 May;78(7):747-758. doi: 10.1007/s40265-018-0903-9. [3]. Tian S, et al. YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo. Cancer Sci. 2011 Jul;102(7):1374-80. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 578.2±50.0 °C at 760 mmHg |
| Molecular Formula | C24H23N5O |
| Molecular Weight | 397.472 |
| Flash Point | 303.5±30.1 °C |
| Exact Mass | 397.190247 |
| PSA | 90.70000 |
| LogP | 3.68 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.652 |
| InChIKey | WPEWQEMJFLWMLV-UHFFFAOYSA-N |
| SMILES | N#CC1(c2ccc(NC(=O)c3cccnc3NCc3ccncc3)cc2)CCCC1 |
Synonyms
| Apatinib |
| N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]nicotinamide |
| 3-Pyridinecarboxamide, N-[4-(1-cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]- |
| YN968D1 |
