Introduction：Basic information about CAS 2316-26-9|3,4-Dimethoxycinnamic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 3,4-Dimethoxycinnamic acid |
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| CAS Number | 2316-26-9 | Molecular Weight | 208.211 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 367.4±27.0 °C at 760 mmHg |
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| Molecular Formula | C11H12O4 | Melting Point | 181-183 °C(lit.) |
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| MSDS | USA | Flash Point | 144.0±17.2 °C |
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Names
| Name | 3,4-Dimethoxycinnamic acid |
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| Synonym | More Synonyms |
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3,4-Dimethoxycinnamic acid BiologicalActivity
| Description | 3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway[1]. Anti-apoptotic effects[1]. |
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| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>ROSResearch Areas >>CancerResearch Areas >>InfectionNatural Products >>Phenylpropanoids |
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| In Vitro | 3,4-Dimethoxycinnamic acid (Methyl ferulic acid; 25, 50 and 100 µM) attenuates the ethanol-induced apoptosis of ethanolexposed L-02 cells[1]. 3,4-Dimethoxycinnamic acid (25, 50 and 100 µM) inhibits the expression levels of Nox4 and p22phox in L-02 cells[1]. 3,4-Dimethoxycinnamic acid (25, 50 and 100 µM) treatment attenuates ethanol-induced MAPK phosphorylation in L-02 cells[1]. 3,4-Dimethoxycinnamic acid decreases the expression levels of superoxide dismutase, catalase and phospholipid hydroperoxide gluthione peroxidase, and downregulates the levels of Bax/Bcl-2 and the cleaved forms of caspase-3 in a dose- and time-dependent manner[1]. |
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| References | [1]. Li L, et al. Methyl ferulic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signalingpathway. Int J Oncol. 2018 Jul;53(1):225-236. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 367.4±27.0 °C at 760 mmHg |
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| Melting Point | 181-183 °C(lit.) |
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| Molecular Formula | C11H12O4 |
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| Molecular Weight | 208.211 |
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| Flash Point | 144.0±17.2 °C |
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| Exact Mass | 208.073563 |
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| PSA | 55.76000 |
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| LogP | 2.24 |
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| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
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| Index of Refraction | 1.574 |
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| Storage condition | -20°C |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26-S37/39 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| HS Code | 2916399090 |
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Customs
| HS Code | 2918990090 |
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| Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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| Biosynthesis of podophyllotoxin in Linum album cell cultures. Planta 215(6) , 1031-9, (2002) Cell cultures of Linum album Kotschy ex Boiss. (Linaceae) showing high accumulation of the lignan podophyllotoxin (PTOX) were established. Enzymological studies revealed highest activities of phenylal... | |
| [Preparation of derivatives of 3-(3,4-dimethoxyphenyl)propanic acid and a study of its biological activity]. Cesk. Farm. 39(3) , 109-12, (1990) From 3-(3,4-dimethoxyphenyl)propenic acid chloride and substituted amines and hydrazides, the appropriate amides and hydrazides (Table 1) were synthesized at 60-80 degrees C in the medium of benzene o... | |
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Synonyms
| RARECHEM BK HC T253 |
| 3-(3,4-Dimethoxyphenyl)-2-propenoic Acid |
| 3,4-Dimethoxy cinnamic acid |
| 3,4-Dimethoxycinnamic acid |
| EINECS 219-025-5 |
| 3-(3,4-Dimethoxyphenyl)acrylic acid |
| o-Methylferulic acid |
| 3,4-Dimethoxy |
| 3,4-Dimethoxycinnami |
| 2-Propenoic acid, 3-(3,4-dimethoxyphenyl)- |
| DIMETHYLCAFFEIC ACID |
| 2-Propenoic acid, 3-(3,4-dimethoxyphenyl)-, (2E)- |
| 3,4-Dimethoxycinnamic Acid, Predominantly trans |
| 3-(3,4-dimethoxyphenyl)propenoic acid |
| 3,4-Dimethoxycinnamic Acid,Predominantly trans |
| MFCD00004387 |
| Methylferulic acid |
| Donepezil Impurity 33 |
