CAS 487-90-1|Porphobilinogen
| Common Name | Porphobilinogen | ||
|---|---|---|---|
| CAS Number | 487-90-1 | Molecular Weight | 226.22900 |
| Density | 1.421g/cm3 | Boiling Point | 478.6ºC at 760 mmHg |
| Molecular Formula | C10H14N2O4 | Melting Point | 174-177ºC |
| MSDS | ChineseUSA | Flash Point | 243.2ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | porphobilinogen |
|---|---|
| Synonym | More Synonyms |
Porphobilinogen BiologicalActivity
| Description | Porphobilinogen could act as a phototoxin, a neurotoxin, and a metabotoxin. |
|---|---|
| Related Catalog | Research Areas >>Metabolic DiseaseNatural Products >>Others |
| Target | Human Endogenous Metabolite |
| In Vitro | Porphobilinogen can act as a phototoxin, a neurotoxin, and a metabotoxin. A phototoxin leads to cell damage upon exposure to light. A neurotoxin causes damage to nerve cells and nerve tissues. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels[1]. |
| References | [1]. Winkelman JW, et al. Neurotoxicity of tetraphenylporphinesulfonate TPPS4 and its relation to photodynamic therapy. Photochem Photobiol. 1987 Nov;46(5):801-7. |
Chemical & Physical Properties
| Density | 1.421g/cm3 |
|---|---|
| Boiling Point | 478.6ºC at 760 mmHg |
| Melting Point | 174-177ºC |
| Molecular Formula | C10H14N2O4 |
| Molecular Weight | 226.22900 |
| Flash Point | 243.2ºC |
| Exact Mass | 226.09500 |
| PSA | 116.41000 |
| LogP | 0.81800 |
| Vapour Pressure | 5.74E-10mmHg at 25°C |
| Index of Refraction | 1.621 |
| InChIKey | QSHWIQZFGQKFMA-UHFFFAOYSA-N |
| SMILES | NCc1[nH]cc(CCC(=O)O)c1CC(=O)O |
| Storage condition | -20°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles39
More Articles| Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting. FASEB J. 29 , 3889-98, (2015) The ubiquitin system plays a critical role in muscle wasting. Previous work has focused on the roles of ubiquitination. However, a role for deubiquitination in this process has not been established. B... | |
| Mass spectrometric characterisation of a condensation product between porphobilinogen and indolyl-3-acryloylglycine in urine of patients with acute intermittent porphyria. J. Mass Spectrom. 50 , 929-37, (2015) We document the presence of a previously unknown species in the urine of patients with acute intermittent porphyria (AIP). The compound was fully characterised by liquid chromatography tandem mass spe... | |
| Crosstalk between the mesothelium and lymphomatous cells: insight into the mechanisms involved in the progression of body cavity lymphomas. Cancer Med. 3(1) , 1-13, (2014) The peculiar localization of body cavity lymphomas implies a specific contribution of the intracavitary microenvironment to the pathogenesis of these tumors. In this study, primary effusion lymphoma (... |
Synonyms
| EINECS 207-666-3 |
| 5-(Aminomethyl)-4-(carboxymethyl)-1H-pyrrole-3-propanoic acid |
| 3-[5-(aminomethyl)-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid |
| Porphobilinogen |
| MFCD00005224 |
