Introduction：Basic information about CAS 55224-05-0|Davercin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Davercin |
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| CAS Number | 55224-05-0 | Molecular Weight | 759.92100 |
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| Density | 1.22 g/cm3 | Boiling Point | 859.8ºC at 760 mmHg |
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| Molecular Formula | C38H65NO14 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Davercin |
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| Synonym | More Synonyms |
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Davercin BiologicalActivity
| Description | Erythromycin Cyclocarbonate, derivative of Erythromycin, which is active against Gram-positive and some Gram-negative microorganisms. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>InfectionNatural Products >>Others |
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| Target | Antibacterial[1] |
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| In Vitro | Erythromycin is used in treatment of respiratory, gastrointestinal, and genital tract infections, as well as skin and soft tissue infections. Erythromycin, with its ten chiral centers and two sugar substituents (L-cladinose and D-desosamine), is a good starting point for numerous medicinal chemistry efforts for improvement of its biological profile (better activity, higher stability, and improved bioavailability) since the first generation of macrolides, which had low toxicity and good tolerability, are unstable in acidic media, had low toxicity and good tolerability[1]. |
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| References | [1]. Jelic D, et al. From Erythromycin to Azithromycin and New Potential Ribosome-Binding Antimicrobials. Antibiotics (Basel). 2016 Sep 1;5(3). pii: E29. |
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Chemical & Physical Properties
| Density | 1.22 g/cm3 |
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| Boiling Point | 859.8ºC at 760 mmHg |
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| Molecular Formula | C38H65NO14 |
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| Molecular Weight | 759.92100 |
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| Exact Mass | 759.44100 |
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| PSA | 188.98000 |
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| LogP | 2.96780 |
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| Index of Refraction | 1.534 |
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| InChIKey | NKLGIWNNVDPGCA-NOVWFWJBSA-N |
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| SMILES | CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)C(=O)C(C)C2OC(=O)OC12C |
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| Storage condition | -20°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- KF4670000
- CHEMICAL NAME :
- Erythromycin, cyclic 11,12-carbonate
- CAS REGISTRY NUMBER :
- 55224-05-0
- LAST UPDATED :
- 199206
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C38-H65-N-O14
- MOLECULAR WEIGHT :
- 760.04
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 31,241,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4050 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 31,241,1974
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Synonyms
| Erythromycin Cyclocarbonate |
| CWE |
| Erythromycin Cyclocarbonate |
| Dravercin |
| Eritromicina A carbonato |
| Carbonato ciclico de eritromicina a |
| Cykliczny weglan erytromycyny a |
| Cykliczny weglan erytromycyny A [polish] |
| erythromycin A cyclic 11,12-carbonate |
| Eritromicina A carbonato [spanish] |
