CAS 2753-45-9|Mebeverine hydrochloride

Introduction：Basic information about CAS 2753-45-9|Mebeverine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Articles26
6. Synonyms

Common Name	Mebeverine hydrochloride
CAS Number	2753-45-9	Molecular Weight	466.01000
Density	/	Boiling Point	543.8ºC at 760mmHg
Molecular Formula	C₂₅H₃₆ClNO₅	Melting Point	105-107ºC
MSDS	ChineseUSA	Flash Point	282.7ºC
Symbol	GHS07	Signal Word	Warning

Names

Name	Mebeverine Hydrochloride
Synonym	More Synonyms

Chemical & Physical Properties

Boiling Point	543.8ºC at 760mmHg
Melting Point	105-107ºC
Molecular Formula	C₂₅H₃₆ClNO₅
Molecular Weight	466.01000
Flash Point	282.7ºC
Exact Mass	465.22800
PSA	57.23000
LogP	5.40450
Vapour Pressure	6.92E-12mmHg at 25°C
InChIKey	PLGQWYOULXPJRE-UHFFFAOYSA-N
SMILES	CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1.Cl
Storage condition	2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YX5425000

CHEMICAL NAME :: Veratric acid, 4-(ethyl(p-methoxy-alpha-methylphenethyl)amino)butyl ester, hydrochloride

CAS REGISTRY NUMBER :: 2753-45-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C25-H35-N-O5.Cl-H

MOLECULAR WEIGHT :: 466.07

WISWESSER LINE NOTATION :: 1OR BO1 DVO4N2&Y1&1R DO1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1540 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2821584

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 17700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2821584

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,338,1972

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	36-26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	YX5425000

Articles26

Validated chromatographic and spectrophotometric methods for analysis of some amoebicide drugs in their combined pharmaceutical preparation.

Pak. J. Pharm. Sci. 26(1) , 175-83, (2013)

This work is concerned with development and validation of chromatographic and spectrophotometric methods for analysis of mebeverine HCl (MEH), diloxanide furoate (DF) and metronidazole (MET) in Dimetr...

Preparation and in vitro evaluation of mebeverine HCl colon-targeted drug delivery system.

Pharm. Dev. Technol. 16(4) , 331-42, (2011)

Mebeverine HCl is a water soluble drug commonly used to treat irritable bowel syndrome by acting directly on the smooth muscles of the colon. This work was aimed at the formulation and in vitro evalua...

Quantitative HPLC analysis of mebeverine, mesalazine, sulphasalazine and dispersible aspirin stored in a Venalink monitored dosage system with co-prescribed medicines.

J. Pharm. Biomed. Anal. 54(4) , 646-52, (2011)

An HPLC method for the quantitative analysis of mebeverine HCl, 5-aminosalicylic acid (5-ASA), sulphasalazine and dispersible aspirin has been developed and then applied to these specific medicines wh...

Synonyms

MFCD00867721

MebeverineHydrochloride

Mebeverine hydrochloride

4-[ethyl-[1-(4-methoxyphenyl)propan-2-yl]amino]butyl 3,4-dimethoxybenzoate,hydrochloride

EINECS 220-400-0

Mebeverine (hydrochloride)

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