Introduction：Basic information about CAS 56495-82-0|irisquinone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | irisquinone |
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| CAS Number | 56495-82-0 | Molecular Weight | 374.55700 |
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| Density | 0.97g/cm3 | Boiling Point | 483.4ºC at 760mmHg |
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| Molecular Formula | C24H38O3 | Melting Point | / |
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| MSDS | / | Flash Point | 205.1ºC |
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Names
| Name | 2-[(Z)-heptadec-10-enyl]-6-methoxycyclohexa-2,5-diene-1,4-dione |
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| Synonym | More Synonyms |
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irisquinone BiologicalActivity
| Description | Irisquinone, a natural product, is an anticancer agent. Irisquinone is also a radiation sensitizer for cancer. Irisquinone reduces GSH level and inhibits the repair of DNA singular strand breaks[1][2][3]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| In Vitro | Irisquinone (0-128 nM, 12-48 h) 诱导大鼠 C6 胶质瘤细胞死亡[2]。 Irisquinone (4.2 nM, 48 h) 增加大鼠 C6 神经胶质瘤细胞的放射敏感性[2]。 Cell Viability Assay[2] Cell Line: C6 rat glioma cells Concentration: 0, 4, 8, 16, 32, 64, 128 nM Incubation Time: 12, 24, 48 h Result: Time-dependently and dose-dependently inhibited cell viability. |
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| In Vivo | Irisquinone (12.5 mg/kg，每日灌注) 使兔 VX2肺移植肿瘤模型中 Irisquinone + 放疗组瘤壁变薄，坏死面积变大[1]。 Animal Model: Rabbit bearing VX2 lung transplant tumor[1] Dosage: 12.5 mg/kg Administration: Perfused daily, starting from 3 days before irradiation to the end of irradiation. Result: Displayed no significant difference of tumor growth between the radio therapy and Irisquinone + radiotherapy groups. Showed thinner tumor wall and the larger necrotic area in the Irisquinone + radiotherapy group. |
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| References | [1]. Xu H, et al. Dynamic observation of the radiosensitive effect of irisquinone on rabbit VX2 lung transplant tumors by using fluorine-18-deoxyglucose positron emission tomography/computed tomography. Nucl Med Commun. 2013 Mar;34(3):220-8. [2]. Wang H, et al. Radiosensitizing effect of irisquinone on glioma through the downregulation of HIF-1α evaluated by 18F-FDG and 18F-FMISO PET/CT. Nucl Med Commun. 2016 Jul;37(7):705-14. [3]. Liang, l., et al. The effect of Irisquinone on the glutathione system and MRP expression of cisplatin-resistant human lung adenocarcinoma cell line (A DDP549). Chin J Cancer Res 13, 171–175 (2001). |
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Chemical & Physical Properties
| Density | 0.97g/cm3 |
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| Boiling Point | 483.4ºC at 760mmHg |
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| Molecular Formula | C24H38O3 |
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| Molecular Weight | 374.55700 |
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| Flash Point | 205.1ºC |
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| Exact Mass | 374.28200 |
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| PSA | 43.37000 |
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| LogP | 6.63240 |
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| Index of Refraction | 1.498 |
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| InChIKey | YYCCUFKHCNSRIA-HJWRWDBZSA-N |
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| SMILES | CCCCCCC=CCCCCCCCCCC1=CC(=O)C=C(OC)C1=O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- GU5309000
- CHEMICAL NAME :
- 2,5-Cyclohexadiene-1,4-dione, 2-(10-heptadecenyl)-6-methoxy-, (Z)-
- CAS REGISTRY NUMBER :
- 56495-82-0
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C24-H38-O3
- MOLECULAR WEIGHT :
- 374.62
- WISWESSER LINE NOTATION :
- L6V DVJ BO1 F10U7
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 2,131,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25400 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 2,131,1981
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Synonyms
| irisquinone A |
| Pallasone |
| Irisquinone |
