Introduction：Basic information about CAS 94841-17-5|Spirapril hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Spirapril hydrochloride |
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| CAS Number | 94841-17-5 | Molecular Weight | 503.07500 |
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| Density | / | Boiling Point | 697.8ºC at 760mmHg |
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| Molecular Formula | C22H31ClN2O5S2 | Melting Point | 192-194ºC (dec.) |
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| MSDS | / | Flash Point | 375.8ºC |
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Names
| Name | (8S)-7-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid,hydrochloride |
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| Synonym | More Synonyms |
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Spirapril hydrochloride BiologicalActivity
| Description | Spirapril (SCH 33844) hydrochloride is a potent angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril competitively binds to ACE and prevents the conversion of angiotensin I to angiotensin II. Spirapril is an orally active prodrug of Spiraprilat and can be used for the research of hypertension, congestive heart failure[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>Angiotensin-converting Enzyme (ACE) |
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| Target | IC50: angiotensin converting enzyme[1] |
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| In Vivo | Spirapril (feeding needle; 10 mg/kg; 3 weeks) decreases alcohol intake in TGM123 mice and dose not reduce the alcohol consumption in TLM mice. Spirapril shows a 40.2% reduction in ACE activity in brain membrane from treated-mice. It crosses the blood-brain barrier and suppresses the transgene effect in the experiments.[2] Animal Model: TGM123 mice (expressing a rat angiotensinogen transgene) and TLM ( lacking the angiotensinogen gene) mice[2] Dosage: 10 mg/kg Administration: Feeding needle; 10 mg/kg; 3 weeks Result: Alter voluntary alcohol consumption in animals. Crossed the blood-brain barrier and may influences alcohol consumption mainly by decreasing central angiotensin II (AII) levels. |
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| References | [1]. Spirapril. Drugbank. [2]. B Maul, et al. Alcohol consumption is controlled by angiotensin II. FASEB J |
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Chemical & Physical Properties
| Boiling Point | 697.8ºC at 760mmHg |
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| Melting Point | 192-194ºC (dec.) |
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| Molecular Formula | C22H31ClN2O5S2 |
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| Molecular Weight | 503.07500 |
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| Flash Point | 375.8ºC |
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| Exact Mass | 502.13600 |
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| PSA | 146.54000 |
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| LogP | 3.52160 |
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| InChIKey | CLDOLNORSLLQDI-OOAIBONUSA-N |
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| SMILES | CCOC(=O)C(CCc1ccccc1)NC(C)C(=O)N1CC2(CC1C(=O)O)SCCS2.Cl |
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Synonyms
| TI 211-950 |
| Sandopril |
| (8S-(7(R*(R*)),8R*))-7-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,4-Dithia-7-azaspiro[4.4]nonane-8-carboxylic acid monohydrochloride |
| (8S)-7-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid hydrochloride (1:1) (non-preferred name) |
| Renormax |
| Spirapril HCl |
| spiprapril hydrochloride |
| (8S)-7-[(2S)-2-{[(2S)-1-Ethoxy-1-oxo-4-phenyl-2-butanyl]amino}propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid hydrochloride (1:1) |
| (8S)-7((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid 1-ethyl ester monohydrochloride |
| spirapril hydrochloride |
