CAS 745-62-0|Prostaglandin F1α
Introduction：Basic information about CAS 745-62-0|Prostaglandin F1α, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Prostaglandin F1α | ||
|---|---|---|---|
| CAS Number | 745-62-0 | Molecular Weight | 356.497 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 526.5±50.0 °C at 760 mmHg |
| Molecular Formula | C20H36O5 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 286.3±26.6 °C |
Names
| Name | prostaglandin F1α |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 526.5±50.0 °C at 760 mmHg |
| Molecular Formula | C20H36O5 |
| Molecular Weight | 356.497 |
| Flash Point | 286.3±26.6 °C |
| Exact Mass | 356.256287 |
| PSA | 97.99000 |
| LogP | 2.60 |
| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
| Index of Refraction | 1.555 |
| InChIKey | DZUXGQBLFALXCR-CDIPTNKSSA-N |
| SMILES | CCCCCC(O)C=CC1C(O)CC(O)C1CCCCCCC(=O)O |
| Storage condition | -20°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 150 mg/kg
- SEX/DURATION :
- female 4-6 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - other measures of fertility
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 1 mg/kg
- SEX/DURATION :
- female 12-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 45 mg/kg
- SEX/DURATION :
- male 15 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 10 mg/kg
- SEX/DURATION :
- female 16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death
MUTATION DATA - TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 3 mg/kg
- REFERENCE :
- INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 21,82,1976
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 3 mg/kg
- REFERENCE :
- INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 21,82,1976
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| RTECS | GY4569700 |
Articles33
More Articles| Influence of human low density and high density lipoprotein cholesterol on the in vitro prostaglandin I2 synthetase activity. Biochim. Biophys. Acta 620(3) , 352-5, (1980) We investigated in vitro the influence of low density lipoprotein (LDL) cholesterol and high density lioprotein (HDL) cholesterol separated from human serum on prostaglandin I2 synthetase activity stu... | |
| Native pentameric C-reactive protein displays more potent pro-atherogenic activities in human aortic endothelial cells than modified C-reactive protein. Atherosclerosis 184(1) , 48-52, (2006) Inflammation is pivotal in atherogenesis. Numerous prospective studies have shown that levels of high sensitive C-reactive protein (CRP) predict cardiovascular events. Recently, data suggests that CRP... | |
| Long-term fenofibrate treatment impairs endothelium-dependent dilation to acetylcholine by altering the cyclooxygenase pathway. Cardiovasc. Res. 75(2) , 398-407, (2007) Experimental studies and opinion articles emphasize that cardiovascular alterations associated with ageing can be improved by the long-term use of fenofibrates. We analyzed the effect of fenofibrate t... |
Synonyms
| protaglandinf1 |
| prostaglandin F1alpha |
| PGF1ALPHA |
| PGF1 |
| (9α,11α,13E,15S)-9,11,15-Trihydroxyprost-13-en-1-oic acid |
| EINECS 234-237-8 |
| PROSTAGLANDIN F1A |
| Prostaglandin F1α |
| prostaglandinf1 |
| PROSTAGLANDINS F1ALPHA |
| syntheticwhitecrystallinesolid |
| MFCD00077862 |
| Prost-13-en-1-oic acid, 9,11,15-trihydroxy-, (9α,11α,13E,15S)- |
