CAS 91183-98-1|UDP-α-D-N-Acetylglucosamine Disodium Salt
| Common Name | UDP-α-D-N-Acetylglucosamine Disodium Salt | ||
|---|---|---|---|
| CAS Number | 91183-98-1 | Molecular Weight | 651.31700 |
| Density | / | Boiling Point | / |
| Molecular Formula | C17H25N3Na2O17P2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | UDP-α-D-N-ACETYLGLUCOSAMINE, DISODIUM SALT |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | UDP-GlcNAc Disodium Salt is a donor substrate of O-GlcNAc transferase (OGT). |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
| In Vitro | OGT is a nucleocytoplasmic glycosyltransferase (uridine diphospho-N--acetylglucosamine:polypeptide β-N-acetylglucosaminyltransferase or O-GlcNAc transferase) assigned to the GT41 family in the CAZY (Carbohydrate-Active enZYme) database. Using UDP-GlcNAc Disodium Salt (UDP-GlcNAc) as the donor substrate, this enzyme modifies thousands of proteins by adding a unique N-acetylglucosamine residue onto acceptor substrates mainly confined within cytosol and nucleus[1]. |
| References | [1]. Lefebvre T, et al. Antibodies and activity measurements for the detection of O-GlcNAc transferase and assay of its substrate, UDP-GlcNAc. Methods Mol Biol. 2013;1022:147-59. |
Chemical & Physical Properties
| Molecular Formula | C17H25N3Na2O17P2 |
|---|---|
| Molecular Weight | 651.31700 |
| Exact Mass | 651.04500 |
| PSA | 331.14000 |
| InChIKey | HXWKMJZFIJNGES-YZVFIFBQSA-L |
| SMILES | CC(=O)NC1C(OP(=O)([O-])OP(=O)([O-])OCC2OC(n3ccc(=O)[nH]c3=O)C(O)C2O)OC(CO)C(O)C1O.[Na+].[Na+] |
| Storage condition | −20°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 22-26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 29349990 |
Articles21
More Articles| Transporter-mediated uptake of UDP-glucuronic acid by human liver microsomes: assay conditions, kinetics, and inhibition. Drug Metab. Dispos. 43(1) , 147-53, (2014) This study characterized the kinetics, variability, and factors that affect UDP-glucuronic acid (UDP-GlcUA) uptake by human liver microsomes (HLM). Biphasic kinetics were observed for UDP-GlcUA uptake... | |
| Enhanced transfer of a photocross-linking N-acetylglucosamine (GlcNAc) analog by an O-GlcNAc transferase mutant with converted substrate specificity. J. Biol. Chem. 290 , 22638-48, (2015) O-Linked β-N-acetylglucosamine (O-GlcNAc) is a post-translational modification of proteins in multicellular organisms. O-GlcNAc modification is catalyzed by the O-GlcNAc transferase (OGT), which trans... | |
| A new antibiotic kills pathogens without detectable resistance. Nature 517(7535) , 455-9, (2015) Antibiotic resistance is spreading faster than the introduction of new compounds into clinical practice, causing a public health crisis. Most antibiotics were produced by screening soil microorganisms... |
Synonyms
| URIDINE 5-DIPHOSPHO-N-ACETYLGLUCOSAMINE |
| MFCD00799985 |
| UDPAG SODIUM SALT |
| UDP-GlcNAc disodium salt |
| EINECS 293-820-5 |
| UDP-A-D-N-ACETYL-GLUCOSAMINE |
| UDPAG |
| UDP-GLCNAC,2NA |
| UDP-GLCNAC,NA2 |
| UDP-N-ACETYLGLUCOSAMINE DISODIUM SALT |
| UDP-N-acetyl-D-glucosamine disodium salt |
| udp-glcnac |
| uridine 5'-diphosphate-N-acetylglucosamine disodium salt |
| UDP-α-D-N-Acetylglucosamine Disodium Salt |
