CAS 480-49-9|Filipin III

Introduction：Basic information about CAS 480-49-9|Filipin III, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Filipin III BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Articles34
7. Synonyms

Common Name	Filipin III
CAS Number	480-49-9	Molecular Weight	654.828
Density	1.2±0.1 g/cm3	Boiling Point	913.9±65.0 °C at 760 mmHg
Molecular Formula	C₃₅H₅₈O₁₁	Melting Point	163-180°C
MSDS	ChineseUSA	Flash Point	279.3±27.8 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	filipin III
Synonym	More Synonyms

Filipin III BiologicalActivity

Description	Filipin III is the major component of Filipin, a 28-membered ring pentaene macrolide antifungal antibiotic produced by S. filipinensis, S. avermitilis and S. miharaensis. Filipin interacts with membrane sterols causing the alteration of membrane structure[1].
Related Catalog	Signaling Pathways >>Anti-infection >>FungalResearch Areas >>Inflammation/Immunology
Target	Fungal[1]
References	[1]. Payero TD, et al. Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives. Microb Cell Fact. 2015 Aug 7;14:114.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	913.9±65.0 °C at 760 mmHg
Melting Point	163-180°C
Molecular Formula	C₃₅H₅₈O₁₁
Molecular Weight	654.828
Flash Point	279.3±27.8 °C
Exact Mass	654.397888
PSA	208.37000
LogP	-0.41
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.536
InChIKey	IMQSIXYSKPIGPD-YQRUMEKGSA-N
SMILES	CCCCCC(O)C1C(=O)OC(C)C(O)C=CC=CC=CC=CC=C(C)C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC1O

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RN9800000

CHEMICAL NAME :: Oxacyclooctacosa-17,19,21,23,25-pentaen-2-one, 4,6,8,10,12,14,16,27-octahydroxy-3- (1-hydroxyhexyl)-17,28-dimethyl-

CAS REGISTRY NUMBER :: 480-49-9

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C35-H58-O11

MOLECULAR WEIGHT :: 654.93

WISWESSER LINE NOTATION :: T-28-OV PU TU VU A&UTJ CYQ5 DQ FQ HQ JQ LQ MQ OQ P1 C&Q D&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
RTECS	RN9800000

Articles34

Cholesterol dependence of collagen and echovirus 1 trafficking along the novel α2β1 integrin internalization pathway.

PLoS ONE 8(2) , e55465, (2013)

We have previously shown that soluble collagen and a human pathogen, echovirus 1 (EV1) cluster α2β1 integrin on the plasma membrane and cause their internalization into cytoplasmic endosomes. Here we ...

Analysis of cholesterol trafficking with fluorescent probes.

Methods Cell Biol. 108 , 367-93, (2012)

Cholesterol plays an important role in determining the biophysical properties of biological membranes, and its concentration is tightly controlled by homeostatic processes. The intracellular transport...

Influence of membrane cholesterol in the molecular evolution and functional regulation of TRPV4.

Biochem. Biophys. Res. Commun. 456(1) , 312-9, (2015)

TRPV4 is involved in several physiological and sensory functions as well as with several diseases and genetic disorders, though the molecular mechanisms for these are unclear. In this work we have ana...

Synonyms

Oxacyclooctacosa-17,19,21,23,25-pentaen-2-one, 4,6,8,10,12,14,16,27-octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyl-, (17E,19E,21E,23E,25E)-

(17E,19E,21E,23E,25E)-4,6,8,10,12,14,16,27-Octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyloxacyclooctacosa-17,19,21,23,25-pentaen-2-one

Filipin III

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