Introduction：Basic information about CAS 225-51-4|BENZ(C)ACRIDINE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | BENZ(C)ACRIDINE |
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| CAS Number | 225-51-4 | Molecular Weight | 229.276 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 446.2±14.0 °C at 760 mmHg |
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| Molecular Formula | C17H11N | Melting Point | 132°C |
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| MSDS | / | Flash Point | 201.4±12.7 °C |
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Names
| Name | benzo[c]acridine |
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| Synonym | More Synonyms |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 446.2±14.0 °C at 760 mmHg |
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| Melting Point | 132°C |
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| Molecular Formula | C17H11N |
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| Molecular Weight | 229.276 |
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| Flash Point | 201.4±12.7 °C |
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| Exact Mass | 229.089142 |
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| PSA | 12.89000 |
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| LogP | 4.63 |
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| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
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| Index of Refraction | 1.783 |
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| InChIKey | OAPPEBNXKAKQGS-UHFFFAOYSA-N |
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| SMILES | c1ccc2nc3c(ccc4ccccc43)cc2c1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- CU2975000
- CHEMICAL NAME :
- Benz(c)acridine
- CAS REGISTRY NUMBER :
- 225-51-4
- BEILSTEIN REFERENCE NO. :
- 0154999
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C17-H11-N
- MOLECULAR WEIGHT :
- 229.29
- WISWESSER LINE NOTATION :
- T D6 B666 CNJ
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2400 mg/kg/67W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 9630 mg/kg/3D-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
MUTATION DATA - TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 1 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 118,103,1983 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 32,129,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 32,129,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987
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Safety Information
| RIDADR | UN 2811 |
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| Packaging Group | III |
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| Hazard Class | 6.1(b) |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Articles25
More Articles
| Substituted benz[a]acridines and benz[c]acridines as mammalian topoisomerase poisons. Bioorg. Med. Chem. 8(5) , 1171-82, (2000) Coralyne and several other synthetic benzo[a,g]quinolizium derivatives related to protoberberine alkaloids have exhibited activity as topoisomerase poisons. These compounds are characterized by the pr... | |
| Heteroatom effects in chemical carcinogenesis: effects of ring heteroatoms on ease of carbocation formation. Cancer Biochem. Biophys. 7(1) , 53-60, (1983) The presence of a heteroatom can influence the ease with which a PAH diol-epoxide forms a triol carbocation. The influence of the heteroatom should be greatest when it is located where the PAH undergo... | |
| Differentiated genotoxic response of carcinogenic and non-carcinogenic benzacridines and metabolites in rat hepatoma cells. Carcinogenesis 6(3) , 455-7, (1985) Two closely related hepatoma cell lines were examined for their genotoxic response to benacridines and their metabolites by the appearance of alkaline labile DNA sites: H5, a dedifferentiated line exp... | |
Synonyms
| 3,4-Benzacridine |
| Benzo[c]acridine |
| 3,4-Benzoacridine |
| BENZ(C)ACRIDINE |
| 12-Azabenz[a]anthracene |
| Benz[c]acridine |
| 7,8-Benzacridine |
