Introduction：Basic information about CAS 35172-59-9|Z-Gly-Gly-Phe-chloromethylketone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Z-Gly-Gly-Phe-chloromethylketone |
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| CAS Number | 35172-59-9 | Molecular Weight | 445.90 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C22H24ClN3O5 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | benzyl N-[2-[[2-[[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]carbamate |
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| Synonym | More Synonyms |
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Z-Gly-Gly-Phe-chloromethylketone BiologicalActivity
| Description | Z-GGF-CMK is a protease inhibitor, inhibits ClpP1P2 and proteasome. Z-GGF-CMK exhibits cytotoxic activity against HepG2 cells with a CC50 value of 125 μM[1]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Metabolic Enzyme/Protease >>Proteasome |
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| References | [1]. Moreira W, et, al. Bortezomib Warhead-Switch Confers Dual Activity against Mycobacterial Caseinolytic Protease and Proteasome and Selectivity against Human Proteasome. Front Microbiol. 2017 Apr 27;8:746. |
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Chemical & Physical Properties
| Molecular Formula | C22H24ClN3O5 |
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| Molecular Weight | 445.90 |
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| Exact Mass | 445.14000 |
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| PSA | 113.60000 |
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| LogP | 2.73710 |
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| InChIKey | JVPOZEGMCMVPAF-SFHVURJKSA-N |
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| SMILES | O=C(CNC(=O)OCc1ccccc1)NCC(=O)NC(Cc1ccccc1)C(=O)CCl |
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Synonyms
| Z-Gly-Gly-Phe chloromethyl ketone |
| Z-Gly-Gly-Phe-chloromethylketone |
