CAS 191338-87-1|Ac-Glu-Ser-Met-Asp-aldehyde (pseudo acid)

Introduction：Basic information about CAS 191338-87-1|Ac-Glu-Ser-Met-Asp-aldehyde (pseudo acid), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Ac-Glu-Ser-Met-Asp-aldehyde (pseudo acid)
CAS Number	191338-87-1	Molecular Weight	506.527
Density	1.4±0.1 g/cm3	Boiling Point	1049.7±65.0 °C at 760 mmHg
Molecular Formula	C₁₉H₃₀N₄O₁₀S	Melting Point	/
MSDS	/	Flash Point	588.6±34.3 °C

Names

Name	ac-esmd-cho
Synonym	More Synonyms

BiologicalActivity

Description	Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site[1][2].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Cell Cycle/DNA Damage >>Casein KinaseSignaling Pathways >>Stem Cell/Wnt >>Casein Kinase
References	[1]. Hayashida M, et al. Cell death induction by CTL: perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma cells. Proc Soc Exp Biol Med. 2000 Nov;225(2):143-50. [2]. Agniswamy J, et al. Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis. FEBS J. 2007 Sep;274(18):4752-65.

Description

Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site[1][2].

Related Catalog

Research Areas >>OthersSignaling Pathways >>Cell Cycle/DNA Damage >>Casein KinaseSignaling Pathways >>Stem Cell/Wnt >>Casein Kinase

References

[1]. Hayashida M, et al. Cell death induction by CTL: perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma cells. Proc Soc Exp Biol Med. 2000 Nov;225(2):143-50.

[2]. Agniswamy J, et al. Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis. FEBS J. 2007 Sep;274(18):4752-65.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	1049.7±65.0 °C at 760 mmHg
Molecular Formula	C₁₉H₃₀N₄O₁₀S
Molecular Weight	506.527
Flash Point	588.6±34.3 °C
Exact Mass	506.168274
PSA	253.60000
LogP	-1.68
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.555
InChIKey	TVTYMGFOGZRIHG-UHFFFAOYSA-N
SMILES	CSCCC(NC(=O)C(CO)NC(=O)C(CCC(=O)O)NC(C)=O)C(=O)NC(C=O)CC(=O)O

Safety Information

WGK Germany	3

Synonyms

ACETYL-GLU-SER-MET-ASPARTINAL

AC-ESMD-ALDEHYDE

N-ACETYL-GLU-SER-MET-ASPARTINAL

AC-GLU-SER-MET-ASP-CHO

L-Methioninamide, N-acetyl-L-α-glutamyl-L-seryl-N-[(1S)-2-carboxy-1-formylethyl]-

Acetyl-glutamyl-serinyl-methionyl-aspartal

N-Acetyl-L-α-glutamyl-L-seryl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-methioninamide

AC-GLU-SER-MET-ASP-ALDEHYDE

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