Introduction：Basic information about CAS 10436-25-6|Boc-11-aminoundecanoic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Boc-11-aminoundecanoic acid |
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| CAS Number | 10436-25-6 | Molecular Weight | 301.42200 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C16H31NO4 | Melting Point | 68 °C |
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| MSDS | ChineseUSA | Flash Point | / |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | Boc-11-aminoundecanoic acid |
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| Synonym | More Synonyms |
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Boc-11-aminoundecanoic acid BiologicalActivity
| Description | Boc-11-aminoundecanoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of MS432 (HY-130602)[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Alkyl/ether |
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| In Vitro | MS432 is a first-in-class and highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
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| References | [1]. Wei J, et al.Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader.J Med Chem. 2019 Dec 12;62(23):10897-10911. |
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Chemical & Physical Properties
| Melting Point | 68 °C |
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| Molecular Formula | C16H31NO4 |
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| Molecular Weight | 301.42200 |
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| Exact Mass | 301.22500 |
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| PSA | 75.63000 |
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| LogP | 4.49750 |
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| InChIKey | HPTPZJBSQUULAV-UHFFFAOYSA-N |
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| SMILES | CC(C)(C)OC(=O)NCCCCCCCCCCC(=O)O |
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| Storage condition | 2-8°C |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H315-H319-H335 |
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| Precautionary Statements | P261-P305 + P351 + P338 |
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| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S22-S24/25 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| HS Code | 2924199090 |
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Customs
| HS Code | 2924199090 |
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| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Articles1
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Synonyms
| 11-((tert-Butoxycarbonyl)amino)undecanoic acid |
| 11-[(2-methylpropan-2-yl)oxycarbonylamino]undecanoic acid |
| MFCD00076902 |
