CAS 695-34-1|Aminopicoline
Introduction：Basic information about CAS 695-34-1|Aminopicoline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Aminopicoline | ||
|---|---|---|---|
| CAS Number | 695-34-1 | Molecular Weight | 108.141 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 227.4±20.0 °C at 760 mmHg |
| Molecular Formula | C6H8N2 | Melting Point | 96-99 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 114.0±9.0 °C |
| Symbol | GHS06, GHS08 | Signal Word | Danger |
Names
| Name | 4-Methylpyridin-2-amine |
|---|---|
| Synonym | More Synonyms |
Aminopicoline BiologicalActivity
| Description | Aminopicoline (Ascensil) is a potent and nonselective inhibitor of NO synthase (NOS) isoenzymes (iNOS, nNOS, eNOS)[1]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Immunology/Inflammation >>NO Synthase |
| References | [1]. Boer R, et al. The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes. Mol Pharmacol. 2000;58(5):1026-1034. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 227.4±20.0 °C at 760 mmHg |
| Melting Point | 96-99 °C(lit.) |
| Molecular Formula | C6H8N2 |
| Molecular Weight | 108.141 |
| Flash Point | 114.0±9.0 °C |
| Exact Mass | 108.068748 |
| PSA | 38.91000 |
| LogP | 1.08 |
| Vapour Pressure | 0.1±0.4 mmHg at 25°C |
| Index of Refraction | 1.574 |
| InChIKey | ORLGLBZRQYOWNA-UHFFFAOYSA-N |
| SMILES | Cc1ccnc(N)c1 |
| Water Solubility | SOLUBLE |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,841,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 160 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 227,234,1955
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 64 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 53,227S,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 39 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 26,345,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,841,1986
Safety Information
| Symbol | GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331-H373 |
| Precautionary Statements | P261-P280-P301 + P310-P311 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T:Toxic |
| Risk Phrases | R25;R36/37/38 |
| Safety Phrases | S53-S45-S60-S61-S37/39-S28A-S26-S36/37/39 |
| RIDADR | UN 3086 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | TJ5150000 |
| Packaging Group | II |
| Hazard Class | 6.1 |
| HS Code | 2932999099 |
Customs
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles23
More Articles| Guide to Receptors and Channels (GRAC), 4th Edition. Br. J. Pharmacol. 158 Suppl 1 , S1-254, (2009) | |
| Synthesis and evaluation of pyrido[1,2-a]pyrimidines as inhibitors of nitric oxide synthases. Eur. J. Med. Chem. 44 , 2877-87, (2009) A series of new 3-aroylpyrido[1,2-a]pyrimidines were synthesized from aryl methyl ketones in a simple two-step procedure and evaluated as nitric oxide synthases (NOS) inhibitors. In order to perform a... | |
| Actions of 4-methyl-2-aminopyridine on neuromuscular transmission and contractility of skeletal muscle. Eur. J. Pharmacol. 70(1) , 53-7, (1981) 4-Methyl-2-aminopyridine (4M2AP) increased responses of isolated rat diaphragm and chick biventer cervicis nerve-muscle preparations to nerve stimulation but depressed responses to direct stimulation.... |
Synonyms
| 2-amino-4-Me-pyridine |
| 2-Amino-4-meyhylpyrimidine |
| MFCD00149166 |
| 2-Pyridinamine,4-methyl |
| 4-methyl-pyridin-2-ylamine |
| 4-Methyl-2-aminopyridine |
| 2-Amino-4-methylpyridine |
| 2-Amino-4-picoline |
| 2-amino-4-methyl-pyridine |
| 4-Methylpyridin-2-amin |
| EINECS 234-190-3 |
| Ascensil |
| 4-Methyl-2-pyridylamine |
| 2-Pyridinamine, 4-methyl- |
| 4-PICOLINAMINE |
| 4-PICOLINE,2-AMINO |
| 4-Methyl-2-pyridinamine |
| 4-Methylpyridin-2-amine |
