CAS 2997-92-4|2,2'-Azobis(2-methylpropionamidine) dihydrochloride
| Common Name | 2,2'-Azobis(2-methylpropionamidine) dihydrochloride | ||
|---|---|---|---|
| CAS Number | 2997-92-4 | Molecular Weight | 271.191 |
| Density | 0.42 | Boiling Point | 267ºC at 760 mmHg |
| Molecular Formula | C8H20Cl2N6 | Melting Point | 160-169 ºC |
| MSDS | ChineseUSA | Flash Point | 115.3ºC |
| Symbol | GHS02, GHS07 | Signal Word | Danger |
Names
| Name | 2,2'-Azobis(2-methylpropionamidine) dihydrochloride |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | AAPH (2,2'-Azodiisobutyramidine dihydrochloride) has an effect of radical generation. AAPH induces oxidative stress and erythrocyte hemolysis[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
| References | [1]. Sean M. Culbertson, et al. Unsymmetrical Azo Initiators Increase Efficiency of Radical Generation in Aqueous Dispersions, Liposomal Membranes, and Lipoproteins. J. Am. Chem. Soc. 2000, 122, 17, 4032–4038. [2]. Liao W, et al. Intracellular antioxidant detoxifying effects of diosmetin on 2,2-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative stress through inhibition of reactive oxygen species generation. J Agric Food Chem. 2014 Aug 27;62(34):8648-54. |
Chemical & Physical Properties
| Density | 0.42 |
|---|---|
| Boiling Point | 267ºC at 760 mmHg |
| Melting Point | 160-169 ºC |
| Molecular Formula | C8H20Cl2N6 |
| Molecular Weight | 271.191 |
| Flash Point | 115.3ºC |
| Exact Mass | 270.112640 |
| PSA | 124.46000 |
| LogP | 4.07180 |
| Vapour Pressure | 8.02E-05mmHg at 25°C |
| InChIKey | LXEKPEMOWBOYRF-UHFFFAOYSA-N |
| SMILES | CC(C)(N=NC(C)(C)C(=N)N)C(=N)N.Cl.Cl |
| Stability | Unstable. Sensitive to heat and light. Incompatible with strong oxidizing agents, strong acids. |
| Water Solubility | acetone, dioxane, methanol, ethanol, DMSO and water: soluble |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0282-0427S ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 410 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0282-0427S
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5900 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0282-0427S
Safety Information
| Symbol | GHS02, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H242-H302-H317 |
| Precautionary Statements | P280 |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R22;R43 |
| Safety Phrases | S24-S37 |
| RIDADR | UN 3226 4.1 |
| WGK Germany | 1 |
| RTECS | UE4575500 |
| Packaging Group | III |
| Hazard Class | 5.1 |
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Synonyms
| 2,2-AZOBIS-(2-AMIDINOPROPANE) HCL |
| AAPH |
| Azostarter V 50 |
| ms1 |
| ABAP |
| 2,2-Azobis(2-Methylpropionamidine) Dihydrochloride |
| ms1(catalyst) |
| v50 |
| 2,2'-Azobis(2 |
| 2,2′-azobis(isobutyramidine) dihydrochloride |
| Propanimidamide, 2,2'-[(E)-1,2-diazenediyl]bis[2-methyl-, hydrochloride (1:2) |
| 2,2‘-Azobis(2-methylpropionamidine) dihydrochloride |
| 2,2'-azobis(2-methyl-2-propionamidine) dihydrochloride |
| 2,2'-azobisi(2-amidinopropane) hydrochloride |
| 2,2'-Azobis(2-methylpropionamidine) Dihydrochloride |
| 2,2'-(Diazene-1,2-diyl)bis(2-methylpropanimidamide) dihydrochloride |
| 2,2'-(e)-diazene-1,2-diylbis(2-methylpropanimidamide) dihydrochloride |
| EINECS 221-070-0 |
| 2,2’-Azodiisobutyramidine Dihydrochloride |
| MFCD00142725 |
| 2,2'-[(E)-1,2-Diazenediyl]bis(2-methylpropanimidamide) dihydrochloride |
| 2,2'-Azobis-amidinopropane |
| AIBA |
| 2,2'-(3-NITROPHENYLIMINO)-DIETHANOL |
| 2,2'-Azobis(isobutyramidine) 2HCl |
