CAS 88-24-4|2,2'-Methylenebis(6-tert-butyl-4-ethylphenol)

Introduction：Basic information about CAS 88-24-4|2,2'-Methylenebis(6-tert-butyl-4-ethylphenol), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Articles7
6. Synonyms

Common Name	2,2'-Methylenebis(6-tert-butyl-4-ethylphenol)
CAS Number	88-24-4	Molecular Weight	368.552
Density	1.0±0.1 g/cm3	Boiling Point	452.1±40.0 °C at 760 mmHg
Molecular Formula	C₂₅H₃₆O₂	Melting Point	119-122 °C(lit.)
MSDS	ChineseUSA	Flash Point	187.5±21.9 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	2,2-Methylenebis(4-Ethyl-6-Tert-Butylphenol)
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	452.1±40.0 °C at 760 mmHg
Melting Point	119-122 °C(lit.)
Molecular Formula	C₂₅H₃₆O₂
Molecular Weight	368.552
Flash Point	187.5±21.9 °C
Exact Mass	368.271515
PSA	40.46000
LogP	8.09
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.544
InChIKey	GPNYZBKIGXGYNU-UHFFFAOYSA-N
SMILES	CCc1cc(Cc2cc(CC)cc(C(C)(C)C)c2O)c(O)c(C(C)(C)C)c1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL9800000

CHEMICAL NAME :: Phenol, 2,2'-methylenebis(6-tert-butyl-4-ethyl-

CAS REGISTRY NUMBER :: 88-24-4

BEILSTEIN REFERENCE NO. :: 2016207

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C25-H36-O2

MOLECULAR WEIGHT :: 368.61

WISWESSER LINE NOTATION :: 1X1&1&R BQ F2 C1R BQ D2 CX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17,135,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17,135,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 80 gm/kg/12W-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17,135,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16800 mg/kg/4W-C

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 18,49,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 32760 mg/kg/78W-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 16,15,1996 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1250 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: AJANA2 American Journal of Anatomy. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1-192, 1901-91. Volume(issue)/page/year: 110,29,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9392 No. of Facilities: 90 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 5106 (estimated) No. of Female Employees: 2789 (estimated)

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	SL9800000

Articles7

Toxicity studies of a synthetic antioxidant, 2,2'-methylenebis (4-ethyl-6-tert-butylphenol) in rats. 2. Uncoupling effect on oxidative phosphorylation of liver mitochondria.

J. Toxicol. Sci. 18(1) , 49-55, (1993)

Effects of 2,2'-methylenebis (4-ethyl-6-tert-butylphenol) (MBEBP) on hepatic mitochondrial oxidative phosphorylation in vitro, and on hepatic peroxisomal enzymes activities and microsomal mixed-functi...

[Distribution of 2,2'-methylenebis (4-ethyl-6-tert-butylphenol) in rat tissues].

Eisei Shikenjo Hokoku. (105) , 26-8, (1987)

[Distribution of 2,2'-methylenebis (4-ethyl-6-tert-butylphenol) in rat fat].

Eisei Shikenjo Hokoku. (106) , 105-6, (1988)

Synonyms

2-tert-butyl-6-[(3-tert-butyl-5-ethyl-2-hydroxyphenyl)methyl]-4-ethylphenol

MFCD00026296

2,2'-Methylenebis[4-ethyl-6-(2-methyl-2-propanyl)phenol]

Phenol, 2,2'-methylenebis[6-(1,1-dimethylethyl)-4-ethyl-

EINECS 201-814-0

2,2'-Methylenebis(6-tert-butyl-4-ethylphenol)

Phenol, 2,2'-methylenebis[6-tert-butyl-4-ethyl-

2,2'-methanediylbis(6-tert-butyl-4-ethylphenol)

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