CAS 23418-85-1|Propargyl-Tos
| Common Name | Propargyl-Tos | ||
|---|---|---|---|
| CAS Number | 23418-85-1 | Molecular Weight | 224.276 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 352.0±25.0 °C at 760 mmHg |
| Molecular Formula | C11H12O3S | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 166.7±23.2 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | but-3-ynyl 4-methylbenzenesulfonate |
|---|---|
| Synonym | More Synonyms |
Propargyl-Tos BiologicalActivity
| Description | Propargyl-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC Linker |
| Target | Cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. |
| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 352.0±25.0 °C at 760 mmHg |
| Molecular Formula | C11H12O3S |
| Molecular Weight | 224.276 |
| Flash Point | 166.7±23.2 °C |
| Exact Mass | 224.050720 |
| PSA | 51.75000 |
| LogP | 2.01 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.535 |
| InChIKey | STOASOOVVADOKH-UHFFFAOYSA-N |
| SMILES | C#CCCOS(=O)(=O)c1ccc(C)cc1 |
| Storage condition | Refrigerator (+4°C) |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R22;R36/37/38 |
| Safety Phrases | S26-S36/37/39-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2905290000 |
Customs
| HS Code | 2905290000 |
|---|---|
| Summary | 2905290000 unsaturated monohydric alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
Articles3
More Articles| Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: synthesis and structure-activity relationships. J. Med. Chem. 39(16) , 3179-87, (1996) A novel series of aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines with dopaminergic activity is described. The structure-activity relationships of this series were studied by synthesis of analo... | |
| A new class of histamine H(3)-receptor antagonists: synthesis and structure-activity relationships of 7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolines. Bioorg. Med. Chem. Lett. 13(13) , 2131-5, (2003) The synthesis and biological evaluation of novel cycloheptaquinoline antagonists of the human H(3) receptor are described. Two series of compounds, bearing either an amino substituent or an alkyne lin... | |
| Synthesis of Antitumor Lycorines by Intramolecular Diels-Alder Reaction. J. Org. Chem. 61(5) , 1650-1654, (1996) Pharmacologically interesting lycorines were obtained by a short, efficient method based on an intramolecular Diels-Alder reaction between an alpha-pyrone and an alkyne, followed by loss of CO(2) in a... |
Synonyms
| 3-Butyn-1-ol, 4-methylbenzenesulfonate |
| p-Toluenesulfonic Acid 3-Butynyl Ester |
| homopropargyl alcohol tosylate |
| 4-tosyloxy-1-butyne |
| 3-butynyl p-tosylate |
| but-3-yn-1-yl tosylate |
| 3-Butyn-1-yl 4-methylbenzenesulfonate |
| 3-Butynyl Tosylate |
| but-3-yn-1-yl p-toluenesulfonate |
| 3-(1-Butynyl)-4-toluenesulphonate |
| But-3-yn-1-yl 4-methylbenzenesulfonate |
| 3-Butynyl 4-methylbenzenesulfonate |
| 3-Butynyl p-toluenesulfonate |
| MFCD00041687 |
