Introduction：Basic information about CAS 55779-06-1|FORTIMICIN, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | FORTIMICIN |
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| CAS Number | 55779-06-1 | Molecular Weight | 405.49000 |
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| Density | 1.31g/cm3 | Boiling Point | 621.1ºC at 760mmHg |
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| Molecular Formula | C17H35N5O6 | Melting Point | >200° (dec) |
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| MSDS | / | Flash Point | 329.4ºC |
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Names
| Name | astromicin |
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| Synonym | More Synonyms |
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FORTIMICIN BiologicalActivity
| Description | Astromicin (KW-1070) is a water-soluble aminoglycoside antibiotic that can be isolated from the genus Micromonospora. Astromicin exhibits broad spectrum antibacterial activity against gram positive and negative bacteria[1][2][3]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | Astromicin 的体外抗菌活性[3] Bacillus subtilis KY 4273 Staphylococcus aureus ATCC 6538P Streptococcus faecalis ATCC 10541 Escherichia coli ATCC 26 E.coli KY 8310 Klebsiella pneumoniae ATCC 10031 Pseudomonas aeruginosa KY 4276 Proteus vulgaris ATCC 6897 Shigella sonnei ATCC 9290 Salmonella typhosa ATCC 9992 MIC (µg/mL) 0.02 0.04 10 0.16 0.13 0.08 5 0.16 0.3 0.08 E.coli ATCC 26 E.coli KY 8302 E.coli KY 8321 E.coli KY 8327 E.coli KY 8332 E.coli KY 8349 Providencia sp. 164 Serratia marcescens POE 1065 MIC (µg/mL) 0.16 0.16 0.08 0.32 0.04 0.08 0.63 0.32 |
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| In Vivo | Astromicin (3.7 mg/kg 和 5.8 mg/kg；皮下注射；单剂量) 对感染 S.aureus Smith 或 E.coli Juhl 的小鼠具有保护作用[3]。 |
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| References | [1]. Dairi T, et al. Organization and nature of fortimicin A (astromicin) biosynthetic genes studied using a cosmid library of Micromonospora olivasterospora DNA. Mol Gen Genet. 1992 Dec;236(1):39-48. [2]. Kawamoto T, et al. Determination of sisomicin, netilmicin, astromicin and micronomicin in serum by high-performance liquid chromatography. J Chromatogr. 1984 Feb 10;305(2):373-9. [3]. Nara T, et al. Fortimicins A and B, new aminoglycoside antibiotics. I. Producing organism, fermentation and biological properties of fortimicins. J Antibiot (Tokyo). 1977 Jul;30(7):533-40. |
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Chemical & Physical Properties
| Density | 1.31g/cm3 |
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| Boiling Point | 621.1ºC at 760mmHg |
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| Melting Point | >200° (dec) |
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| Molecular Formula | C17H35N5O6 |
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| Molecular Weight | 405.49000 |
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| Flash Point | 329.4ºC |
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| Exact Mass | 405.25900 |
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| PSA | 192.54000 |
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| InChIKey | BIDUPMYXGFNAEJ-APGVDKLISA-N |
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| SMILES | COC1C(O)C(N)C(OC2OC(C(C)N)CCC2N)C(O)C1N(C)C(=O)CN |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NM7521490
- CHEMICAL NAME :
- L-chiro-Inositol, 4-amino-1-((aminoacetyl)methylamino)-1,4-dideoxy-3-O- (2,6-diamino- 2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O- methyl-
- CAS REGISTRY NUMBER :
- 55779-06-1
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C17-H35-N5-O6
- MOLECULAR WEIGHT :
- 405.57
- WISWESSER LINE NOTATION :
- T6OTJ CZ FYZ1 BO- AL6TJ BZ CQ DO1 EN1&V1Z FQ
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 97 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 29,543,1986
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Synonyms
| antibiotickw-1070 |
| XK-70-1 |
| FORTIMYCIN |
| ASTROMICIN SULPHATE |
| Fortimycin A |
| ASTROMYCIN |
| FORTIMICIN |
| fortimicina |
| kw-1070 |
