CAS 26645-35-2|phallacidin

Introduction：Basic information about CAS 26645-35-2|phallacidin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. phallacidin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles26
7. Synonyms

Common Name	phallacidin
CAS Number	26645-35-2	Molecular Weight	846.90400
Density	1.54 g/cm3	Boiling Point	1435.2ºC
Molecular Formula	C₃₇H₅₀N₈O₁₃S	Melting Point	/
MSDS	ChineseUSA	Flash Point	821.8ºC
Symbol	GHS06	Signal Word	Danger

Names

Name	phallacidin
Synonym	More Synonyms

phallacidin BiologicalActivity

Description	Phallacidin is a natural mycotoxin first isolated from the death cap mushroom, A. phalloides. Phallacidin binds filamentous actin (F-actin) like phalloidin (Item No. 18039), but contains a carboxyl group for coupling reactions.
Related Catalog	Signaling Pathways >>Others >>Others

Chemical & Physical Properties

Density	1.54 g/cm3
Boiling Point	1435.2ºC
Molecular Formula	C₃₇H₅₀N₈O₁₃S
Molecular Weight	846.90400
Flash Point	821.8ºC
Exact Mass	846.32200
PSA	354.22000
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.683
InChIKey	KUBDTFZQCYLLGC-UHFFFAOYSA-N
SMILES	CC1NC(=O)C2CC(O)CN2C(=O)C2CSc3[nH]c4ccccc4c3CC(NC1=O)C(=O)NC(CC(C)(O)CO)C(=O)NC(C(C)C)C(=O)NC(C(O)C(=O)O)C(=O)N2
Storage condition	-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GT8943000

CHEMICAL NAME :: cyclic(L-Alanyl-2-mercapto-L-tryptophyl-4,5-dihydroxy -L-leucyl-L-valyl-ery thro-3-hydroxy- D-alpha-aspartyl-L-cysteinyl-cis-4-hydroxy-L-prolyl) cyclic (2-6)-sulfide

CAS REGISTRY NUMBER :: 26645-35-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C37-H50-N8-O13-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CRBCAI CRC Critical Reviews in Biochemistry. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1972- Volume(issue)/page/year: 5,185,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 22,2142,1972

Safety Information

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300-H310-H330
Precautionary Statements	P260-P264-P280-P284-P302 + P350-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T+: Very toxic;
Risk Phrases	R26/27/28
Safety Phrases	S22;S45;S36/S37/S39
RIDADR	UN 1544
RTECS	GT8943000
Hazard Class	6.1(a)

Articles26

Intestinal epithelial cytoskeleton selectively constrains lumen-to-tissue migration of neutrophils.

Am. J. Physiol. 271(1 Pt 1) , C312-20, (1996)

Migration of neutrophils (polymorphonuclear leukocytes; PMN) across polarized epithelia is asymmetrical: basolateral-to-apical (physiologically directed) migration is far more efficient than migration...

A concept study on identification and attribution profiling of chemical threat agents using liquid chromatography-mass spectrometry applied to Amanita toxins in food.

Forensic Sci. Int. 221(1-3) , 44-9, (2012)

Accidental or deliberate poisoning of food is of great national and international concern. Detecting and identifying potentially toxic agents in food is challenging due to their large chemical diversi...

Direct binding of F actin to the cytoplasmic domain of the alpha 2 integrin chain in vitro.

Biochem. Biophys. Res. Commun. 217(2) , 466-74, (1995)

The transmembrane integrins have been shown to interact with the cytoskeleton via noncovalent binding between cytoplasmic domains (CDs) of integrin beta chains and various actin binding proteins withi...

Synonyms

Cyclo[L-Ala-L-Trp2(1)-4,5-dihydroxy-L-Leu-L-Val-[(3S)-3-hydroxy-D-Asp-]-L-Cys(1)-L-c4Hyp-]

Cyclo(Ala-2-Mercapto-Trp-4,5-Dihydroxy-Leu-Val-erythro-3-Hydroxy-D-Asp-Cys-cis-4-Hydroxy-Pro)

PHALLICIDIN

cyclic(l-alanyl-2-mercapto-l-tryptophyl-4,5-dihydroxy-l-leucyl-l-valyl-erythro

CYCLO[ALA-2-MERCAPTO-TRP-4,5-DIHYDROXY-LEU-VAL-ERYTHRO-3-HYDROXY-D-ASP-CYS-CIS-4-HYDROXY-PRO]

PHALLACIDIN

MFCD00063359

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