CAS 566-65-4|5α-Dihydroprogesterone

Introduction：Basic information about CAS 566-65-4|5α-Dihydroprogesterone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 5α-Dihydroprogesterone BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Synonyms

Common Name	5α-Dihydroprogesterone
CAS Number	566-65-4	Molecular Weight	316.478
Density	1.0±0.1 g/cm3	Boiling Point	429.2±38.0 °C at 760 mmHg
Molecular Formula	C₂₁H₃₂O₂	Melting Point	204 °C
MSDS	/	Flash Point	160.3±23.8 °C

Names

Name	5α-pregnane-3,20-dione
Synonym	More Synonyms

5α-Dihydroprogesterone BiologicalActivity

Description	5a-Pregnane-3,20-dione is the endogenous progesterone metabolite.
Related Catalog	Research Areas >>EndocrinologyNatural Products >>Flavonoids
Target	Human Endogenous Metabolite
In Vitro	5a-Pregnane-3,20-dione decreases cell-substrate attachment, adhesion plaques, vinculin expression, and polymerizes F-actin in MCF-7 breast cancer cells[1].
References	[1]. Wiebe JP, et al. The endogenous progesterone metabolite, 5a-pregnane-3,20-dione, decreases cell-substrate attachment, adhesion plaques, vinculin expression, and polymerized F-actin in MCF-7 breast cancer cells. Endocrine. 2001 Oct;16(1):7-14.

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	429.2±38.0 °C at 760 mmHg
Melting Point	204 °C
Molecular Formula	C₂₁H₃₂O₂
Molecular Weight	316.478
Flash Point	160.3±23.8 °C
Exact Mass	316.240234
PSA	34.14000
LogP	4.31
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.516
InChIKey	XMRPGKVKISIQBV-BJMCWZGWSA-N
SMILES	CC(=O)C1CCC2C3CCC4CC(=O)CCC4(C)C3CCC12C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4157150

CHEMICAL NAME :: 5-beta-Pregnane-3,20-dione

CAS REGISTRY NUMBER :: 566-65-4

BEILSTEIN REFERENCE NO. :: 2058506

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H32-O2

MOLECULAR WEIGHT :: 316.53

WISWESSER LINE NOTATION :: L E5 B666 OVTJ A1 E1 FV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,117,1968

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,117,1968

Safety Information

Hazard Codes	Xi
WGK Germany	3
RTECS	TU4157150

Synonyms

5a-Dihydroprogesterone

4-07-00-02199 (Beilstein Handbook Reference)

Pregnane-3,20-dione, (5-α)- (9CI)

5alpha-Pregnan-3,20-dione

MFCD00067132

Allopregnane-3,20-dione

(5S,8R,9S,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one

UNII:98G4S1OH0Z

5α-pregnane-3,20-dione

(5α)-Pregnane-3,20-dione

Pregnane-3,20-dione

5α-dihydroprogesterone

EINECS 209-297-3

Allopregnan-3,20-dione

3,20-Allopregnanedione

5alpha-pregnane-3,20-dione

3,20-Dioxo-5a-pregnane

5a-Pregnan-3,20-dione

Pregnane-3,20-dione, (5α)-

Pregnane-3,20-dione, (5α)- (9CI)

3,20-Dioxo-5alpha-pregnane

5-α-pregnane-3,20-dione

allopregnandione

5alpha-Dihydroprogesterone

5a-Pregnane-3,20-dione

5α-Pregnane-3,20-dione (8CI)

(5Alpha)-Pregnane-3,20-dione

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