Introduction：Basic information about CAS 481704-21-6|tans-4-Hydroxy-D-proline methyl ester hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | tans-4-Hydroxy-D-proline methyl ester hydrochloride |
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| CAS Number | 481704-21-6 | Molecular Weight | 181.617 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C6H12ClNO3 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | (2R,4S)-Methyl 4-hydroxypyrrolidine-2-carboxylatehydrochloride |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | tans-4-Hydroxy-D-proline methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Non-cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
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| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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Chemical & Physical Properties
| Molecular Formula | C6H12ClNO3 |
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| Molecular Weight | 181.617 |
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| Exact Mass | 181.050568 |
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| PSA | 58.56000 |
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| LogP | 0.01300 |
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| InChIKey | KLGSHNXEUZOKHH-UYXJWNHNSA-N |
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| SMILES | COC(=O)C1CC(O)CN1.Cl |
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Synonyms
| Trans-4-hydroxy-L-proline methyl ester hydrochloride |
| 1-Hydroxy-pentan-2-on |
| Methyl (4R)-4-hydroxy-L-prolinate hydrochloride (1:1) |
| 1-hydroxy-pentan-2-one |
| Hydroxymethyl-propyl-keton |
| 1-Hydroxy-2-pentanone |
| 2-Pentanone,1-hydroxy |
| l-hydroxy-2-oxopentane |
| L-hydroxyproline methyl ester hydrochloride |
| L-Proline, 4-hydroxy-, methyl ester, (4R)-, hydrochloride (1:1) |
| 4S-hydroxy-1-pyrrolidine-2R-carboxylic acid methyl ester hydrochloride salt |
| 1-hydroxy-2-oxopentane |
