CAS 197250-15-0|GAP 26 trifluoroacetate salt

Introduction：Basic information about CAS 197250-15-0|GAP 26 trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. GAP 26 trifluoroacetate salt BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	GAP 26 trifluoroacetate salt
CAS Number	197250-15-0	Molecular Weight	1550.78
Density	/	Boiling Point	/
Molecular Formula	C₇₀H₁₀₆N₁₉O₁₉S	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	Gap 26
Synonym	More Synonyms

GAP 26 trifluoroacetate salt BiologicalActivity

Description	Gap 26 is a connexin mimetic peptide corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker.
Related Catalog	Signaling Pathways >>Cytoskeleton >>Gap Junction ProteinResearch Areas >>Cardiovascular DiseasePeptides
Target	Gap Junction Protein[1]
In Vitro	Gap 26 is corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker. Gap 26 (100-300 μM) dose-dependently reduces the rhythmic responses of rabbit superior mesenteric arteries, with IC50 of 28.4 ± 3.4 μM[1]. Gap 26 abolishes the inositol-1,4,5-trisphosphate (InsP3)-triggered ATP response and reduces the ATP release, but has no effect on gap junctional coupling[2].
References	[1]. Chaytor AT, et al. Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries. J Physiol. 1997 Aug 15;503 ( Pt 1):99-110. [2]. Braet K, et al. Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26. Cell Calcium. 2003 Jan;33(1):37-48.

Chemical & Physical Properties

Molecular Formula	C₇₀H₁₀₆N₁₉O₁₉S
Molecular Weight	1550.78
PSA	657.12000
LogP	1.84770
InChIKey	FDPIMWZHGJNESB-VCSXYVMHSA-N
SMILES	CCC(C)C(NC(=O)C1CCCN1C(=O)C(Cc1ccccc1)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C(CC(=O)O)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CS)NC(=O)C(N)C(C)C)C(=O)NC(CO)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(C(=O)NC(CCCN=C(N)N)C(=O)O)C(C)C
Storage condition	2-8℃

Synonyms

Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg

M.W. 1550.78 C70H107N19O19S

VCYDKSFPISHVR

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