Introduction：Basic information about CAS 112192-04-8|Roxindole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Roxindole |
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| CAS Number | 112192-04-8 | Molecular Weight | 346.47 |
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| Density | 1.173g/cm3 | Boiling Point | 575.7ºC at 760mmHg |
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| Molecular Formula | C23H26N2O | Melting Point | / |
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| MSDS | / | Flash Point | 302ºC |
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Names
| Name | roxindole |
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| Synonym | More Synonyms |
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Roxindole BiologicalActivity
| Description | Roxindole (EMD 49980), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor with high affinity for 5-HT1A (IC50=0.9 nM). Antipsychotic and antidepressant activities[1][2][3]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>Serotonin Transporter |
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| In Vivo | Roxindole (EMD 49980) (1, 3, 10 mg/kg; s.c) inhibits both effects of 8-OH- DPAT (flat body and forepaw treading) in normal rats (male Wistar 200-350g)[3]. Roxindole inhibits apomorphine-induced climbing in mice and stereotyped behavior in rats with ED50s of 1.4 mg/kg s.c. and 0.65 mg/kg s.c., respectively, and inhibits conditioned avoidance response in rats (ED50=1.5 mg/kg s.c.)[4]. |
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| References | [1]. Bartoszyk GD, Harting J, Minck KO. Roxindole: psychopharmacological profile of a dopamine D2 autoreceptor agonist. J Pharmacol Exp Ther. 1996;276(1):41-48. [2]. Wetzel H, et al. Roxindole, a dopamine autoreceptor agonist, in the treatment of positive and negative schizophrenic symptoms. Am J Psychiatry. 1994;151(10):1499-1502. [3]. Maj J, et al. Roxindole, a dopamine autoreceptor agonist with a potential antidepressant activity. II. Effects on the 5-hydroxytryptamine system. Pharmacopsychiatry. 1997;30(2):55-61. [4]. Bartoszyk GD, et al. Roxindole: psychopharmacological profile of a dopamine D2 autoreceptor agonist. J Pharmacol Exp Ther. 1996;276(1):41-48. |
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Chemical & Physical Properties
| Density | 1.173g/cm3 |
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| Boiling Point | 575.7ºC at 760mmHg |
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| Molecular Formula | C23H26N2O |
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| Molecular Weight | 346.47 |
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| Flash Point | 302ºC |
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| Exact Mass | 346.20500 |
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| PSA | 39.26000 |
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| LogP | 4.92340 |
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| Vapour Pressure | 7.46E-14mmHg at 25°C |
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| Index of Refraction | 1.651 |
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| InChIKey | HGEYJZMMUGWEOT-UHFFFAOYSA-N |
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| SMILES | Oc1ccc2[nH]cc(CCCCN3CC=C(c4ccccc4)CC3)c2c1 |
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Roxindole |
| RoxindoleHCl |
| Roxindole hydrochloride,3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-olhydrochloride |
| ROXINDOLE HYDROCHLORIDE |
