CAS 56092-82-1|Ionomycin calcium salt
Introduction：Basic information about CAS 56092-82-1|Ionomycin calcium salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ionomycin calcium salt | ||
|---|---|---|---|
| CAS Number | 56092-82-1 | Molecular Weight | 747.067 |
| Density | / | Boiling Point | 817.2ºC at 760mmHg |
| Molecular Formula | C41H70CaO9 | Melting Point | 205-206ºC |
| MSDS | ChineseUSA | Flash Point | 235.2ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Ionomycin calcium salt from Streptomyces conglobatus |
|---|---|
| Synonym | More Synonyms |
Ionomycin calcium salt BiologicalActivity
| Description | Ionomycin (calcium) is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelResearch Areas >>CancerResearch Areas >>Infection |
| Target | Calcium channel[1]. |
| In Vitro | Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus[1]. Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca2+ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells as supported by simultaneously positive fluorescein labeling and propidium iodide uptake. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment[2]. |
| References | [1]. Liu C, et al. Characterization of ionomycin as a calcium ionophore. J Biol Chem. 1978 Sep 10;253(17):5892-4. [2]. Gil-Parrado S, et al. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem. 2002 Jul 26;277(30):27217-26. |
Chemical & Physical Properties
| Boiling Point | 817.2ºC at 760mmHg |
|---|---|
| Melting Point | 205-206ºC |
| Molecular Formula | C41H70CaO9 |
| Molecular Weight | 747.067 |
| Flash Point | 235.2ºC |
| Exact Mass | 746.464600 |
| PSA | 131.75000 |
| LogP | 7.64540 |
| InChIKey | WKRWUYKLUMMAKG-WYGBAUISSA-L |
| SMILES | CC(CCC(=O)[O-])CC(C)CC(C)C(=O)C=C([O-])C(C)CC(C)CC=CC(C)C(O)C(C)C(O)CC1CCC(C)(C2CCC(C)(C(C)O)O2)O1.[Ca+2] |
| Storage condition | 2-8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 650 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978 Volume(issue)/page/year: 3,47,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 12 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978 Volume(issue)/page/year: 3,47,1978
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | 22 |
| Safety Phrases | 36 |
| RIDADR | NONH for all modes of transport |
| RTECS | NO0650000 |
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Synonyms
| Ionomycin calcium salt |
| 10,16-Docosadienoic acid, 11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-, calcium salt, (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)- (1:1) |
| MFCD00151183 |
| Calcium (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-19,21-dihydroxy-22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxo-10,16-docosadienoate |
