Introduction：Basic information about CAS 70006-24-5|ABT-724, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ABT-724 |
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| CAS Number | 70006-24-5 | Molecular Weight | 293.36600 |
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| Density | 1.275g/cm3 | Boiling Point | 548.6ºC at 760 mmHg |
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| Molecular Formula | C17H19N5 | Melting Point | / |
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| MSDS | / | Flash Point | 285.6ºC |
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Names
| Name | ABT 724 trihydrochloride,2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazoletrihydrochloride |
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| Synonym | More Synonyms |
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ABT-724 BiologicalActivity
| Description | ABT-724 is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM). ABT-724 has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 could be useful for the treatment of erectile dysfunction and has favorable side-effect profile[1]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease |
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| Target | EC50: 12.4 nM (Human dopamine D4 receptor), 14.3 nM (Rat dopamine D4 receptor) and 23.2 nM (Ferret dopamine D4 receptor)[1] |
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| In Vitro | ABT-724 exhibits a selective biochemical profile, as indicates by a lack of binding affinity for >70 neurotransmitter/uptake/ion channels including D2, D3, or D5 receptors up to a 10 μM concentration. A weak affinity to 5-HT1A receptors (Ki = 2780 nM) is observed. ABT-724 does not inhibit the PDE activity of PDE1, PDE5, or PDE6 at 10 μM concentrations[1]. |
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| In Vivo | ABT-724 (8.8 μg/kg; subcutaneous injection; daily; for 5 days; male adult Wistar rats) treatment dose-dependently facilitates penile erection when given s.c. to conscious rats[1]. Animal Model: Male adult Wistar rats (~300 g)[1] Dosage: 8.8 μg/kg Administration: Subcutaneous injection; daily; for 5 days Result: Dose-dependently facilitated penile erection. |
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| References | [1]. Brioni JD, et al. Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6758-63. |
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Chemical & Physical Properties
| Density | 1.275g/cm3 |
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| Boiling Point | 548.6ºC at 760 mmHg |
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| Molecular Formula | C17H19N5 |
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| Molecular Weight | 293.36600 |
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| Flash Point | 285.6ºC |
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| Exact Mass | 293.16400 |
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| PSA | 48.05000 |
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| LogP | 2.28300 |
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| Index of Refraction | 1.687 |
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| InChIKey | FRPJGTNLZNXQEX-UHFFFAOYSA-N |
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| SMILES | c1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1 |
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Safety Information
Synonyms
| abt 724 trihydrochloride |
| abt 724 |
