CAS 141992-47-4|NSC 625987

Introduction：Basic information about CAS 141992-47-4|NSC 625987, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. NSC 625987 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	NSC 625987
CAS Number	141992-47-4	Molecular Weight	271.33400
Density	1.32g/cm3	Boiling Point	460.4ºC at 760 mmHg
Molecular Formula	C₁₅H₁₃NO₂S	Melting Point	/
MSDS	/	Flash Point	232.2ºC

Names

Name	1,4-dimethoxy-10H-acridine-9-thione
Synonym	More Synonyms

NSC 625987 BiologicalActivity

Description	NSC 625987 is a specific and high-affinity CDK4 inhibitor with an IC50 of 0.2 μM for CDK4:cyclin D1. NSC 625987 shows >500-fold selectivity for CDK4 over CDK2[1].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>CDK
Target	CDK4/D1:0.2 μM (IC50)
In Vitro	NSC 625987 (10 nM, 50 nM, 100 nM) treatment attenuates the enhanced proliferation of vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) rats by about 35%[2].
References	[1]. A Kubo, et al. The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin Cancer Res. 1999 Dec;5(12):4279-86. [2]. Jasmine El Andalousi, et al.Natriuretic peptide receptor-C agonist attenuates the expression of cell cycle proteins and proliferation of vascular smooth muscle cells from spontaneously hypertensive rats: role of Gi proteins and MAPkinase/PI3kinase signaling. PLoS One. 2013 Oct 14;8(10):e76183.

Chemical & Physical Properties

Density	1.32g/cm3
Boiling Point	460.4ºC at 760 mmHg
Molecular Formula	C₁₅H₁₃NO₂S
Molecular Weight	271.33400
Flash Point	232.2ºC
Exact Mass	271.06700
PSA	66.34000
LogP	4.06780
Vapour Pressure	1.17E-08mmHg at 25°C
Index of Refraction	1.683
InChIKey	KFAKESMKRPNZTM-UHFFFAOYSA-N
SMILES	COc1ccc(OC)c2c(=S)c3ccccc3[nH]c12

Synonyms

1,4-Dimethoxy-9-thio(10H)-acridone

Tocris-2152

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