Introduction：Basic information about CAS 209481-20-9|SB271046, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | SB271046 |
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| CAS Number | 209481-20-9 | Molecular Weight | 488.45100 |
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| Density | 1.400 | Boiling Point | 664.3ºC at 760 mmHg |
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| Molecular Formula | C20H23Cl2N3O3S2 | Melting Point | 240-241℃ (DEC.) |
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| MSDS | / | Flash Point | 355.5ºC |
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Names
| Name | SB 271046 hydrochloride |
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| Synonym | More Synonyms |
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SB271046 BiologicalActivity
| Description | SB 271046 is a potent, selective and orally active 5-HT6 receptor antagonist with a pKi of 8.92-9.09. SB 271046 show >200-fold selective for the 5-HT6 receptor over other receptors, binding sites and ion channels. SB 271046 has anticonvulsant activity[1]. |
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| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
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| Target | 5-HT6 Receptor:8.92-9.09 (pKi) |
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| In Vitro | In functional studies on human 5-HT6 receptors SB 271046 competitively antagonized 5-HT-induced stimulation of adenylyl cyclase activity with a pA2 of 8.71[1]. |
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| In Vivo | SB 271046 produces an increase in seizure threshold over a wide-dose range in the rat maximal electroshock seizure threshold (MEST) test, with a minimum effective dose of ⩽0.1 mg/kg p.o. and maximum effect at 4 h post-dose. The level of anticonvulsant activity achieved correlated well with the blood concentrations of SB 271046 (EC50 of 0.16 μM) and brain concentrations of 0.01-0.04 μM at Cmax[1]. |
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| References | [1]. C Routledge, et al. Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist. Br J Pharmacol. 2000 Aug;130(7):1606-12. |
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Chemical & Physical Properties
| Density | 1.400 |
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| Boiling Point | 664.3ºC at 760 mmHg |
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| Melting Point | 240-241℃ (DEC.) |
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| Molecular Formula | C20H23Cl2N3O3S2 |
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| Molecular Weight | 488.45100 |
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| Flash Point | 355.5ºC |
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| Exact Mass | 487.05600 |
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| PSA | 107.29000 |
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| LogP | 6.43170 |
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| InChIKey | LOCQRDBFWSXQQI-UHFFFAOYSA-N |
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| SMILES | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCNCC1 |
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| Storage condition | Desiccate at RT |
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Synonyms
| 5-Chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-methyl-1-benzothiophene-2-sulfonamide hydrochloride (1:1) |
| Benzo[b]thiophene-2-sulfonamide, 5-chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methyl-, hydrochloride (1:1) |
| 5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methyl-1-benzothiophene-2-sulfonamide hydrochloride (1:1) |
| Benzo[b]thiophene-2-sulfonamide (5-chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methyl |
| SB271046 |
