CAS 186901-48-4|Cortistatin 14
| Common Name | Cortistatin 14 | ||
|---|---|---|---|
| CAS Number | 186901-48-4 | Molecular Weight | 1721.01000 |
| Density | / | Boiling Point | / |
| Molecular Formula | C81H114N20O18S2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | Cortistatin-14 |
|---|---|
| Synonym | More Synonyms |
Cortistatin 14 BiologicalActivity
| Description | Cortistatin-14, a neuropeptide have structural similarity to somatostatin-14, binds and exerts its function via the somatostatin receptors (sst1-sst5). Cortistatin-14 shows anticonvulsive, neuroprotective effect and remarkable anti-inflammatory properties[1][2][3][4]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Somatostatin ReceptorResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease |
| References | [1]. De Lecea L, et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature. 1996 May 16;381(6579):242-5. [2]. Baranowska B, et al. Cortistatin and pituitary hormone secretion in rat. J Physiol Pharmacol. 2009 Mar;60(1):151-6. [3]. Braun H, et al. Protective effects of cortistatin (CST-14) against kainate-induced neurotoxicity in rat brain. Brain Res. 1998 Aug 24;803(1-2):54-60. [4]. Markovics A, et al. Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systems. J Mol Neurosci. 2012 Jan;46(1):40-50. |
Chemical & Physical Properties
| Molecular Formula | C81H114N20O18S2 |
|---|---|
| Molecular Weight | 1721.01000 |
| Exact Mass | 1719.79000 |
| PSA | 675.86000 |
| LogP | 3.12890 |
| InChIKey | DDRPLNQJNRBRNY-WYYADCIBSA-N |
| SMILES | CC(O)C1NC(=O)C(CCCCN)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2ccccc2)NC(=O)C(CC(N)=O)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C2CCCN2)CSSCC(C(=O)NC(CCCCN)C(=O)O)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(Cc2ccccc2)NC1=O |
| Storage condition | −20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles4
More Articles| The cortical neuropeptide, cortistatin-14, impairs post-training memory processing. Brain Res. 775 , 250-252, (1997) Cortistatin-14, a neuropeptide, is present primarily in the cortex and hippocampus. In the hippocampus, cortistatin-14 inhibits pyramidal cell firing and co-exists with GABA. To determine if cortistat... | |
| Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res. Brain Res. Rev. 33 , 228-241, (2000) Cortistatin is a recently discovered neuropeptide relative of somatostatin named after its predominantly cortical expression and ability to depress cortical activity. Cortistatin-14 shares 11 of the 1... | |
| Structural and compositional determinants of cortistatin activity. J. Neurosci. 56 , 611-619, (1999) Cortistatin-14 (CST-14) is a putative novel neuropeptide that shares 11 of its 14 residues with somatostatin-14 (SRIF-14), yet its effects on sleep physiology, locomotor behavior and hippocampal funct... |
Synonyms
| cortistatin14 |
| Cortistatin 14 |
