CAS 113731-96-7|RFARKGALRQKNVHEVKN

Introduction:Basic information about CAS 113731-96-7|RFARKGALRQKNVHEVKN, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameRFARKGALRQKNVHEVKN
CAS Number113731-96-7Molecular Weight2151.48
Density/Boiling Point/
Molecular FormulaC93H159N35O24Melting Point/
MSDS/Flash Point/

Names

Namepkc (19-36)
SynonymMore Synonyms

RFARKGALRQKNVHEVKN BiologicalActivity

DescriptionProtein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM. Protein Kinase C (19-36) markedly attenuated vascular hyperproliferation and hypertrophy as well as glucose-induced suppression of natriuretic peptide receptor response[1].
Related CatalogSignaling Pathways >>Epigenetics >>PKCResearch Areas >>OthersSignaling Pathways >>TGF-beta/Smad >>PKC
Target

IC50: 0.18 μM (protein kinase C)[1].

References

[1]. Yasunari K, et al. Possible involvement of phospholipase D and protein kinase C in vascular growth induced by elevated glucose concentration. Hypertension. 1996 Aug;28(2):159-68.

Chemical & Physical Properties

Molecular FormulaC93H159N35O24
Molecular Weight2151.48
Exact Mass2150.23000
PSA1017.03000
LogP4.05580
InChIKeyNHCJMYZDRROLEW-UHFFFAOYSA-N
SMILESCC(C)CC(NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)NC(=O)C(Cc1ccccc1)NC(=O)C(N)CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(N)=O)C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(Cc1c[nH]cn1)C(=O)NC(CCC(=O)O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)O)C(C)C)C(C)C

Safety Information

Hazard CodesXi

Synonyms

protein kinase c selective inhibitor
protein kinase c fragment
protein kinase c fragment 19-36
pkc selective inhibitor protein
rfarkgalrqknvhevkn
pkc selective inhibitor
h2n-rfarkgalrqknvhevkn-oh
pkc 19-36
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