CAS 123714-50-1|Acetyl-Calpastatin (184-210) (human) trifluoroacetate salt

Introduction：Basic information about CAS 123714-50-1|Acetyl-Calpastatin (184-210) (human) trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameAcetyl-Calpastatin (184-210) (human) trifluoroacetate salt
CAS Number123714-50-1Molecular Weight3177.63000
Density/Boiling Point/
Molecular FormulaC142H230N36O44SMelting Point/
MSDS/Flash Point/

Names

NameAcetyl-Calpastatin (184-210) (human)

BiologicalActivity

DescriptionAcetyl-Calpastatin(184-210)(human) is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for µ-calpain and cathepsin L, respectively[1][2].
Related CatalogResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Metabolic Enzyme/Protease >>Proteasome
In VitroAcetyl-Calpastatin(184-210)(human) (peptide 1; 12.5-100 μM) inhibits calpains in LCLC 103H cells with an IC50 of 27 μM[1].
References

[1]. Ferdinando Fiorino, et al. A new cell-permeable calpain inhibitor. J Pept Sci. 2007 Jan;13(1):70-3.

[2]. Benjamin P Davis, et al. Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. JCI Insight. 2016 Apr;1(4):e86355.

Chemical & Physical Properties

Molecular FormulaC142H230N36O44S
Molecular Weight3177.63000
Exact Mass3175.66000
PSA1311.44000
LogP3.43000
Appearance of Characterspowder
InChIKeyZXJCOYBPXOBJMU-HSQGJUDPSA-N
SMILESCCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CCSC)NC(=O)C1CCCN1C(=O)C(CC(=O)O)NC(C)=O)C(C)O)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)O)C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1CCCC1C(=O)N1CCCC1C(=O)NC(CCCCN)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)C(N)=O)C(C)CC)C(C)O)C(C)C
Storage condition−20°C
Water SolubilityH2O: 1 mg/mL

Safety Information

WGK Germany3
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