CAS 12279-41-3|ACTH (1-39) (human)
Introduction：Basic information about CAS 12279-41-3|ACTH (1-39) (human), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ACTH (1-39) (human) | ||
|---|---|---|---|
| CAS Number | 12279-41-3 | Molecular Weight | 4541.07000 |
| Density | / | Boiling Point | / |
| Molecular Formula | C207H308N56O58S | Melting Point | / |
| MSDS | USA | Flash Point | / |
| Symbol | GHS07, GHS08 | Signal Word | Warning |
Names
| Name | acth (1-39) |
|---|---|
| Synonym | More Synonyms |
ACTH (1-39) (human) BiologicalActivity
| Description | Adrenocorticotropic Hormone (ACTH) (1-39), human is a melanocortin receptor agonist. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic DiseasePeptides |
| Target | Melanocortin receptor[1] |
| In Vitro | Adrenocorticotropic Hormone (ACTH) (1-39), human (ACTH 1-39), a member of the melanocortin family, stimulates production of CS by the adrenals, but melanocortin receptors are also found in the central nervous system (CNS) and on immune cells. ACTH 1-39 protects neurons in vitro from several apoptotic, excitotoxic and inflammation-related insults[1]. The conditioned medium (CM) is prepared from untreated astroglia (AS) cultures and from AS cultures treated with 200 nM ACTH 1-39 for 24 h, washed to remove ACTH 1-39, then incubated for another 24 h in DMEM. In initial experiments, no difference is found in oligodendroglia (OL) viability in the presence of OL definedmediumwith 2% newborn calf serum (NCS) or AS CM (prepared in DMEM with no serum). After 24 h, OL death under each condition varies between 1 and 4%. Similar results for OL viability are obtained with microglia (MG) CM. In subsequent experiments, controls in each experiment consist of OL in defined medium with 2% NCS[2]. |
| Cell Assay | For analysis of the effects of ACTH 1-39 or CM on oligodendroglia (OL) death, purified OL cultures are incubated with ACTH 1-39 at 200 nM or the various CM for 30 min before addition of the toxic agents. Cell death is assessed after 1 day using trypan blue uptake as the indicator of cell death. Trypan blue is considered a preferred method for measurement of total cell death compared to terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL), which measures only apoptosis, or live/dead fluorescent assays, which may not detect permeable dead cells with degraded DNA, thus underestimating cell death. Differentiated OL are identified by their characteristicmorphology, that is, rounded or oval birefringent cells with multiple lacy branching processes, and in some cases by immunostaining with antibodies to galactolipids[2]. |
| References | [1]. Lisak RP, et al. Melanocortin receptor agonist ACTH 1-39 protects rat forebrain neurons from apoptotic, excitotoxic and inflammation-related damage. Exp Neurol. 2015 Nov;273:161-7. [2]. Lisak RP, et al. The melanocortin ACTH 1-39 promotes protection of oligodendrocytes by astroglia. J Neurol Sci. 2016 Mar 15;362:21-6. |
Chemical & Physical Properties
| Molecular Formula | C207H308N56O58S |
|---|---|
| Molecular Weight | 4541.07000 |
| Exact Mass | 4538.26000 |
| PSA | 1861.55000 |
| LogP | 5.65470 |
| InChIKey | IDLFZVILOHSSID-UHFFFAOYSA-N |
| SMILES | CSCCC(NC(=O)C(CO)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(N)CO)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCC(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)N1CCCC1C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(Cc1ccc(O)cc1)C(=O)N1CCCC1C(=O)NC(CC(N)=O)C(=O)NCC(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)NC(Cc1ccccc1)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1ccccc1)C(=O)O)C(C)C)C(C)C)C(C)C |
| Storage condition | −20°C |
| Water Solubility | H2O: 1 mg/mL, clear, colorless |
Safety Information
| Symbol | GHS07, GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H332-H351 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R20/21/22 |
| Safety Phrases | 22-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | GM7900000 |
Articles1
More Articles| Adrenocorticotropins. 44. Total synthesis of the human hormone by the solid-phase method. J. Am. Chem. Soc. 95 , 1310-1315, (1973) |
Synonyms
| Seractide |
| CORTICOTROPHIN |
| M.W. 4541.07 C207H308N56O58S |
| ADRENOCORTICOTROPIC HORMONE HUMAN |
| ACTH |
| Adrenocorticotropic Hormone human |
| ACTH 1-39 |
| CORTICOTROPIN A |
| Adrenocorticotropic Hormone (ACTH) (1-39), human |
